Rabbit anti-Mouse, Rat CD144/VE Cadherin Polyclonal Antibody | anti-CD144/VE antibody

CD144/VE Cadherin polyclonal antibody

Cat. Num. AAA3013396

• Gene Names: Cdh5; 7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA408225
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: CD144/VE Cadherin; Polyclonal Antibody; CD144/VE Cadherin polyclonal antibody; VE-cadherin; 7B4 antigen; VECD; Vascular endothelial cell cadherin; 7B 4; 7B4; Cadherin 5; Cadherin 5 type 2; Cadherin-5; Cadherin5; CD 144; CD144 antigen; CDH 5; CDH5; CDH5 protein; Vascular endothelial cadherin; VE Cad antibody VEC; CADH5_HUMAN. ; anti-CD144/VE antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Specificity: CD144/VE Cadherin polyclonal Antibody detects endogenous levels of CD144/VE Cadherin protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-CD144/VE antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from mouse CD144/VE Cadherin:46-140/784
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Anti-CD144/VE Cadherin at 1/1000 dilution)

Related Product Information for anti-CD144/VE antibody

This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008].

NCBI and Uniprot Product Information

• NCBI GI #: 38490561
• NCBI GeneID: 12562
• NCBI Accession #: NP_033998.2
• NCBI GenBank Nucleotide #: NM_009868.4
• UniProt Accession #: P55284; O35542
• Molecular Weight: 87,903 Da
• NCBI Official Full Name: cadherin-5 preproprotein
• NCBI Official Synonym Full Names: cadherin 5
• NCBI Official Symbol: Cdh5
• NCBI Official Synonym Symbols: 7B4; Vec; VECD; Cd144; VEcad; VE-Cad; AA408225
• NCBI Protein Information: cadherin-5
• UniProt Protein Name: Cadherin-5
• UniProt Gene Name: Cdh5
• UniProt Synonym Gene Names: VE-cadherin
• UniProt Entry Name: CADH5_MOUSE

Uniprot Description

CDH5: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. Interacts via cadherin 5 domain with PTPRB. Interacts with TRPC4. Interacts with KRIT1. Endothelial tissues and brain.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Cellular Component: adherens junction; cell junction; cell surface; external side of plasma membrane; intercellular junction; tight junction

Molecular Function: beta-catenin binding; protein binding; protein phosphatase binding; receptor binding

Biological Process: blood vessel maturation; cell-cell adhesion; intercellular junction assembly; negative regulation of cell proliferation; transforming growth factor beta receptor signaling pathway