Western Blot (WB)
(Anti-CCR5 antibody, MBS176277, Western blottingLane 1: Mouse Lung Tissue LysateLane 2: Mouse Intestine Tissue LysateLane 3: Mouse Kidney Tissue Lysate )
Rabbit anti-Mouse CCR5 Polyclonal Antibody | anti-CCR5 antibody
Anti-CCR5 antibody
Western Blot (WB)
(Anti-CCR5 antibody, MBS176277, Western blottingLane 1: Mouse Lung Tissue LysateLane 2: Mouse Intestine Tissue LysateLane 3: Mouse Kidney Tissue Lysate )
Western Blot (WB)
(Anti-CCR5 antibody, MBS176277, Western blottingLane 1: Mouse Lung Tissue LysateLane 2: Mouse Intestine Tissue LysateLane 3: Mouse Kidney Tissue Lysate )
Background: Human CC chemokine receptor 5(CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus(HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.
NCBI and Uniprot Product Information
Uniprot Description
CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection
Protein type: Membrane protein, multi-pass; Receptor, cytokine; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, integral; Receptor, GPCR
Cellular Component: cell surface; membrane; cytoplasm; integral to membrane; plasma membrane; cytosol; endosome; external side of plasma membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity; C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; actin binding; glycoprotein binding; protein kinase binding
Biological Process: calcium-mediated signaling; positive regulation of interleukin-6 production; defense response; positive regulation of interleukin-1 beta secretion; negative regulation of axon extension; chemotaxis; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; positive regulation of tumor necrosis factor production; signal transduction; positive regulation of apoptosis by virus; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell-cell signaling; calcium ion transport; positive regulation of fever; positive regulation of cell-cell adhesion; immune response; positive regulation of neuron differentiation; inflammatory response; negative regulation of cell migration; positive regulation of inflammatory response
Research Articles on CCR5
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Product Notes
The CCR5 ccr5 (Catalog #AAA176277) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CCR5 antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCR5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CCR5 ccr5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCR5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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