Typical Testing Data/Standard Curve (for reference only)
Mouse C-C chemokine receptor type 5 ELISA Kit | Ccr5 elisa kit
Mouse C-C chemokine receptor type 5 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
CCR5: a 7-transmembrane G-linked receptor for a number of inflammatory C-C type chemokines including MIP-1-alpha, MIP-1-beta and RANTES. Transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (along with CD4) for HIV-1 R5 isolates. Interacts with PRAF2. Interacts with HIV-1 surface protein gp120. Efficient ligand binding to CCL3/MIP-1alpha and CCR4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on S6 is required for efficient binding of CCL4. Interacts with ADRBK1. Interacts with ARRB1 and ARRB2. Variations in CCR5 are associated with resistance or susceptibility to immunodeficiency virus type 1 (resistance or susceptibility to HIV-1). Variations in CCR5 gene also influence the rate of progression to AIDS after infection. R60S variant, a naturally occurring mutation in a conserved residue in the first intracellular domain of CCR5, results in reduced amounts of the protein in the membrane and consequently may be associated with reduced susceptibility to infection by microbes that depend on these molecules as their receptors. Variations in CCR5 are associated with susceptibility to West Nile virus (WNV) infection
Protein type: Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, cytokine
Cellular Component: cell surface; cytoplasm; cytosol; endosome; external side of plasma membrane; integral to membrane; membrane; plasma membrane
Molecular Function: actin binding; C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; G-protein coupled receptor activity; glycoprotein binding; protein kinase binding; signal transducer activity
Biological Process: calcium ion transport; calcium-mediated signaling; cell-cell signaling; chemotaxis; defense response; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; negative regulation of axon extension; negative regulation of cell migration; positive regulation of apoptosis by virus; positive regulation of cell-cell adhesion; positive regulation of fever; positive regulation of inflammatory response; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of neuron differentiation; positive regulation of tumor necrosis factor production; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; signal transduction
Research Articles on Ccr5
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Product Notes
The Mouse Ccr5 ccr5 (Catalog #AAA2884218) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2884218 ELISA Kit recognizes Mouse Ccr5. It is sometimes possible for the material contained within the vial of "C-C chemokine receptor type 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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