Western Blot (WB)
(WB Suggested Anti-Ccnd1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Mouse Small Intestine)
Rabbit Ccnd1 Polyclonal Antibody | anti-CCND1 antibody
Ccnd1 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-Ccnd1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Mouse Small Intestine)
Western Blot (WB)
(WB Suggested Anti-Ccnd1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Mouse Small Intestine)
Western Blot (WB)
(WB Suggested Anti-Ccnd1 antibody Titration: 1 ug/mLSample Type: Human MCF7)
Western Blot (WB)
(WB Suggested Anti-Ccnd1 antibody Titration: 1 ug/mLSample Type: Human MCF7)
Target Description: Ccnd1 is essential for the control of the cell cycle at the G1/S (start) transition.
NCBI and Uniprot Product Information
Uniprot Description
CCND1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb.
Protein type: Nuclear receptor co-regulator; Activator; Cell cycle regulation; Oncoprotein
Cellular Component: nucleoplasm; tight junction; membrane; transcriptional repressor complex; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; nucleus
Molecular Function: protein binding; enzyme binding; histone deacetylase binding; protein complex binding; kinase activity; cyclin-dependent protein kinase regulator activity; transcription corepressor activity; transcription factor binding; protein kinase binding; protein kinase activity
Biological Process: lactation; fat cell differentiation; G1 DNA damage checkpoint; negative regulation of Wnt receptor signaling pathway; re-entry into mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; regulation of cell cycle; positive regulation of mammary gland epithelial cell proliferation; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; Leydig cell differentiation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; Wnt receptor signaling pathway; transcription, DNA-dependent; unfolded protein response; mammary gland epithelial cell proliferation; response to organic nitrogen; cell cycle; cell division; positive regulation of protein amino acid phosphorylation; regulation of cyclin-dependent protein kinase activity; regulation of protein kinase activity; response to DNA damage stimulus; G1/S transition of mitotic cell cycle
Research Articles on CCND1
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Product Notes
The CCND1 ccnd1 (Catalog #AAA3204837) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Ccnd1 antibody - C-terminal region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Ccnd1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CCND1 ccnd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: PDCLRACQEQ IEALLESSLR QAQQNVDPKA TEEEGEVEEE AGLACTPTDV. It is sometimes possible for the material contained within the vial of "Ccnd1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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