Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Catenin Beta 1 (CTNNb1) Polyclonal Antibody | anti-CTNNb1 antibody
Polyclonal Antibody to Catenin Beta 1 (CTNNb1)
MGHHHHHHSGS-LG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF RMSED
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
NCBI Description
involved in mediating the interaction between cadherins and the actin cytoskeleton [RGD, Feb 2006]
Uniprot Description
CTNNB1: a regulator of cell adhesion and a key downstream effector in the Wnt signaling pathway. Implicated early embryonic development and tumorigenesis. Phosphorylated and destabilized by CK1 and GSK-3beta. Stabilized cytoplasmic beta-catenin is a hallmark of a variety of cancers. Stabilized beta-catenin translocates to the nucleus, where it acts as a transcriptional activator of T-cell factor (TCF)-regulated genes. Interacts with the PDZ domain of TAX1BP3, inhibiting its transcriptional activity. Two alternatively spliced human isoforms have been described.
Protein type: Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 8q32
Cellular Component: adherens junction; apical junction complex; apical part of cell; basolateral plasma membrane; beta-catenin destruction complex; beta-catenin-TCF complex; beta-catenin-TCF7L2 complex; bicellular tight junction; catenin complex; catenin-TCF7L2 complex; cell cortex; cell junction; cell periphery; cell projection membrane; cell-cell adherens junction; centrosome; cytoplasm; cytosol; dendritic shaft; extracellular exosome; fascia adherens; flotillin complex; focal adhesion; intercalated disc; intercellular junction; intracellular; lamellipodium; lateral plasma membrane; membrane; microvillus membrane; neuron projection; nuclear euchromatin; nuclear membrane; nuclear transcription factor complex; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; Scrib-APC-beta-catenin complex; spindle pole; synapse; transcription factor complex; Wnt signalosome; Z disc
Molecular Function: alpha-catenin binding; cadherin binding; chromatin binding; DNA binding; DNA binding transcription factor activity; double-stranded DNA binding; enzyme binding; estrogen receptor binding; I-SMAD binding; ion channel binding; ionotropic glutamate receptor binding; kinase binding; nitric-oxide synthase binding; nuclear hormone receptor binding; protein binding; protein C-terminus binding; protein complex binding; protein heterodimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; SMAD binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding
Biological Process: animal organ development; anterior/posterior axis specification; bone resorption; branching involved in blood vessel morphogenesis; branching involved in ureteric bud morphogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; cell adhesion; cell differentiation; cell fate determination; cell fate specification; cell maturation; cell proliferation; cell-matrix adhesion; cellular morphogenesis during differentiation; cellular process; cellular protein localization; cellular response to fibroblast growth factor stimulus; cellular response to growth factor stimulus; cellular response to indole-3-methanol; cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; central nervous system vasculogenesis; chromatin-mediated maintenance of transcription; cranial skeletal system development; dorsal/ventral axis specification; dorsal/ventral pattern formation; ectoderm development; embryonic axis specification; embryonic brain development; embryonic digit morphogenesis; embryonic foregut morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; endoderm formation; endodermal cell fate commitment; endothelial tube morphogenesis; fallopian tube development; forebrain development; gastrulation with mouth forming second; genitalia morphogenesis; glial cell fate determination; hair cycle process; hair follicle morphogenesis; heart development; hemopoiesis; hindbrain development; in utero embryonic development; kidney development; layer formation in cerebral cortex; lens morphogenesis in camera-type eye; limb development; liver development; lung development; male genitalia development; metanephros morphogenesis; midbrain development; midbrain dopaminergic neuron differentiation; midgut development; morphogenesis of embryonic epithelium; myoblast differentiation; negative regulation of angiogenesis; negative regulation of apoptotic signaling pathway; negative regulation of cell differentiation; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of gene expression; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of mitotic cell cycle, embryonic; negative regulation of neuron death; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein sumoylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nephron tubule formation; neural plate development; neuron differentiation; neuron migration; odontogenesis of dentine-containing teeth; oocyte development; osteoclast differentiation; pancreas development; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of chromatin-mediated maintenance of transcription; positive regulation of core promoter binding; positive regulation of determination of dorsal identity; positive regulation of DNA-templated transcription, initiation; positive regulation of endothelial cell differentiation; positive regulation of epithelial cell differentiation; positive regulation of epithelial to mesenchymal transition; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of gene expression; positive regulation of heparan sulfate proteoglycan biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of neuroblast proliferation; positive regulation of neuron apoptotic process; positive regulation of osteoblast differentiation; positive regulation of skeletal muscle tissue development; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein heterooligomerization; protein localization to cell surface; proximal/distal pattern formation; regulation of apoptosis; regulation of calcium ion import; regulation of cell differentiation; regulation of cell proliferation; regulation of centriole-centriole cohesion; regulation of core promoter binding; regulation of epithelial cell differentiation; regulation of euchromatin binding; regulation of gene expression; regulation of myelination; regulation of nephron tubule epithelial cell differentiation; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of protein localization to cell surface; regulation of secondary heart field cardioblast proliferation; regulation of smooth muscle cell proliferation; regulation of T cell proliferation; regulation of timing of anagen; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; renal inner medulla development; renal outer medulla development; renal system development; renal vesicle formation; response to activity; response to cadmium ion; response to cytokine; response to drug; response to estradiol; response to estrogen; response to hormone; response to organic cyclic compound; Schwann cell proliferation; skeletal system development; skin development; smooth muscle cell differentiation; synapse organization; synaptic transmission; synaptic vesicle transport; T cell differentiation; T cell differentiation in thymus; thymus development; transcription, DNA-dependent; vasculature development; vasculogenesis; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Research Articles on CTNNb1
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Product Notes
The CTNNb1 ctnnb1 (Catalog #AAA2003696) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Catenin Beta 1 (CTNNb1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Catenin Beta 1 (CTNNb1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CTNNb1 ctnnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG S-LG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF RMSED. It is sometimes possible for the material contained within the vial of "Catenin Beta 1 (CTNNb1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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