Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Catechol-O-Methyltransferase (COMT) Polyclonal Antibody | anti-COMT antibody
Polyclonal Antibody to Catechol-O-Methyltransferase (COMT)
MGHHHHHHSGSEF- GWGLVAIG WFEFVQQPVH NLLMGGTKEQ RILRHVQQHA KPGDPQSVLE AIDTYCSEKE WAMNVGDAKG QIMDAVIREY RPSLVLELGA YCGYSAVRMA RLLPPGARLL TMEINPDYAA ITQQMLDFAG LQDKVSILIG ASQDLIPQLK KKYDVDTLDM VFLDHWKDRY LPDTLLLEEC GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY LEYMKVVDGL EKAVYQGPGS SPVKS
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:MouseTissue))
NCBI and Uniprot Product Information
Uniprot Description
COMT: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Belongs to the mammalian catechol-O-methyltransferase family. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Amino Acid Metabolism - tyrosine; EC 2.1.1.6; Membrane protein, integral; Methyltransferase
Chromosomal Location of Human Ortholog: 16 A3|16 11.4 cM
Cellular Component: axon; cell body; cytoplasm; cytosol; dendrite; dendritic spine; extracellular exosome; integral component of membrane; membrane; mitochondrion; plasma membrane; postsynaptic membrane
Molecular Function: catechol O-methyltransferase activity; L-dopa O-methyltransferase activity; magnesium ion binding; metal ion binding; methyltransferase activity; O-methyltransferase activity; transferase activity
Biological Process: catechol-containing compound metabolic process; catecholamine metabolic process; cellular response to phosphate starvation; dopamine catabolic process; dopamine metabolic process; estrogen metabolic process; female pregnancy; learning; methylation; multicellular organismal reproductive process; negative regulation of dopamine metabolic process; negative regulation of smooth muscle cell proliferation; neurotransmitter catabolic process; positive regulation of homocysteine metabolic process; regulation of sensory perception of pain; response to pain; short-term memory
Research Articles on COMT
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Product Notes
The COMT comt (Catalog #AAA2004110) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Catechol-O-Methyltransferase (COMT) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Catechol-O-Methyltransferase (COMT) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the COMT comt for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF- GWGLVAIG WFEFVQQPVH NLLMGGTKEQ RILRHVQQHA KPGDPQSVLE AIDTYCSEKE WAMNVGDAKG QIMDAVIREY RPSLVLELGA YCGYSAVRMA RLLPPGARLL TMEINPDYAA ITQQMLDFAG LQDKVSILIG ASQDLIPQLK KKYDVDTLDM VFLDHWKDRY LPDTLLLEEC GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY LEYMKVVDGL EKAVYQGPGS SPVKS. It is sometimes possible for the material contained within the vial of "Catechol-O-Methyltransferase (COMT), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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