Western Blot (WB)
(Western blot analysis of extracts of mouse lung tissue, using CASP12 antibody.)
Rabbit anti-Human, Mouse CASP12 Polyclonal Antibody | anti-CASP12 antibody
CASP12 (Caspase 12, CASP12P1) (AP)
WB: 1:500-1:1000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of mouse lung tissue, using CASP12 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of mouse lung tissue, using CASP12 antibody.)
NCBI and Uniprot Product Information
NCBI Description
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
CASP12: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF. Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.22.-
Chromosomal Location of Human Ortholog: 11q22.3
Cellular Component: cytoplasm
Molecular Function: cysteine-type endopeptidase activity
Biological Process: regulation of apoptosis; unfolded protein response; regulation of inflammatory response; proteolysis
Research Articles on CASP12
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Product Notes
The CASP12 casp12 (Catalog #AAA6409567) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CASP12 (Caspase 12, CASP12P1) (AP) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CASP12 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:20-1:200 WB: 1:500-1:1000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CASP12 casp12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CASP12, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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