Immunohistochemistry (IHC)
(Staining on paraffin embedded human hepatocellular carcinoma sections. Primary Ab at 10 ug/ml. Antigen retrieval used: 10 mM Na Citrate pH 6.0, 10 minutes pressure cooker method, developed with anti rabbit HRP and DAP substrate. Counterstained with methyl blue.)
Rabbit anti-Human Calcium Homeostasis Modulator Protein 1 Polyclonal Antibody | anti-CALHM1 antibody
Calcium Homeostasis Modulator Protein 1
Immunohistochemistry (IHC)
(Staining on paraffin embedded human hepatocellular carcinoma sections. Primary Ab at 10 ug/ml. Antigen retrieval used: 10 mM Na Citrate pH 6.0, 10 minutes pressure cooker method, developed with anti rabbit HRP and DAP substrate. Counterstained with methyl blue.)
Immunohistochemistry (IHC)
(Staining on paraffin embedded human hepatocellular carcinoma sections. Primary Ab at 10 ug/ml. Antigen retrieval used: 10 mM Na Citrate pH 6.0, 10 minutes pressure cooker method, developed with anti rabbit HRP and DAP substrate. Counterstained with methyl blue.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]
Uniprot Description
Function: Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner. Ref.3 Ref.5 Ref.6 Ref.7 Ref.8
Enzyme regulation: Inhibited by Gd3+, Ruthenium Red, and Zn2+ and partially inhibited by 2-aminoethoxydiphenyl borate. Ref.6
Subunit structure: Homohexamer. Ref.3 Ref.7
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note: Colocalizes with HSPA5 at the endoplasmic reticulum. Ref.3 Ref.6 Ref.7
Tissue specificity: Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. Ref.3 Ref.4
Polymorphism: Leu-86 causes a dysregulation of Ca2+ homeostasis and amyloid precursor protein (APP) metabolism and has been suggested to be a risk factor for the development of Alzheimer disease (Ref.3, Ref.15, Ref.16). However, this association with Alzheimer disease could not be confirmed in a number of studies performed in different populations (Ref.9, Ref.10, Ref.11, Ref.12, Ref.13, Ref.14, Ref.18). According to a meta-analysis study, Leu-86 is likely not a genetic determinant of Alzheimer disease but may modulate age of onset by interacting with the effect of the APOE*4 allele of the APOE gene (Ref.17).
Sequence similarities: Belongs to the FAM26 family.
Research Articles on CALHM1
Similar Products
Product Notes
The CALHM1 calhm1 (Catalog #AAA395798) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Calcium Homeostasis Modulator Protein 1 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Calcium Homeostasis Modulator Protein 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the CALHM1 calhm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcium Homeostasis Modulator Protein 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
