Rabbit anti-Human, Mouse Calcium homeostasis modulator protein 1 Polyclonal Antibody | anti-CALHM1 antibody

Rabbit anti-human Calcium homeostasis modulator protein 1 polyclonal Antibody(CALHM1)

Cat. Num. AAA1493491

• Gene Names: CALHM1; FAM26C
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Antigen Affinity Purified
• Synonyms: Calcium homeostasis modulator protein 1; Polyclonal Antibody; Rabbit anti-human Calcium homeostasis modulator protein 1 polyclonal Antibody(CALHM1); Protein FAM26C; CALHM1; FAM26C; anti-CALHM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Sequence Length: 346

• Applicable Applications for anti-CALHM1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Recommended dilution: WB:1:500-5000
• Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Conjugate: Non-conjugated
• Immunogen: Recombinant human Calcium homeostasis modulator protein 1 protein (202-346aa)
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-164315
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: Calcium homeostasis modulator protein 1 antibody at 7ug/ml+mouse liver tissueSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 38kDaObserved band size: 38kDa)

Related Product Information for anti-CALHM1 antibody

Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca2+ concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca2+, Na+ and K+, as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner.

NCBI and Uniprot Product Information

• NCBI GI #: 194440685
• NCBI GeneID: 255022
• NCBI Accession #: NP_001001412.3
• NCBI GenBank Nucleotide #: NM_001001412.3
• UniProt Accession #: Q8IU99; Q5W091
• Molecular Weight: 38,264 Da
• NCBI Official Full Name: calcium homeostasis modulator protein 1
• NCBI Official Synonym Full Names: calcium homeostasis modulator 1
• NCBI Official Symbol: CALHM1
• NCBI Official Synonym Symbols: FAM26C
• NCBI Protein Information: calcium homeostasis modulator protein 1
• UniProt Protein Name: Calcium homeostasis modulator protein 1
• Protein Family: Calcium homeostasis modulator protein
• UniProt Gene Name: CALHM1
• UniProt Synonym Gene Names: FAM26C
• UniProt Entry Name: CAHM1_HUMAN

NCBI Description

This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]

Uniprot Description

CALHM1: May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. Belongs to the FAM26 family.

Protein type: Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane

Molecular Function: calcium activated cation channel activity; identical protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity

Biological Process: ATP transport; cation transport; protein homooligomerization; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste