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Western Blot (WB) (CADM2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CADM2 antibody detected the CADM2 protein (arrow).)

Rabbit CADM2 Polyclonal Antibody | anti-CADM2 antibody

CADM2 Antibody (N-term)

Gene Names
CADM2; NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CADM2; Polyclonal Antibody; CADM2 Antibody (N-term); Cell adhesion molecule 2; Immunoglobulin superfamily member 4D; IgSF4D; Nectin-like protein 3; NECL-3; Synaptic cell adhesion molecule 2; SynCAM 2; IGSF4D; NECL3; anti-CADM2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CADM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-76 amino acids from the N-terminal region of human CADM2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
50-76
Sequence Length
327
Applicable Applications for anti-CADM2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Clone Names
RB37833
Function
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
Cellular Location
Cell membrane; Single-pass type I membrane protein Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(CADM2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CADM2 antibody detected the CADM2 protein (arrow).)

Western Blot (WB) (CADM2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CADM2 antibody detected the CADM2 protein (arrow).)
Related Product Information for anti-CADM2 antibody
Members of the large immunoglobulin (Ig) superfamily, such
as IGSF4D, have diverse roles in extracellular recognition and
intercellular adhesion (Biederer, 2006 [PubMed 16311015]).[supplied
by OMIM].
Product Categories/Family for anti-CADM2 antibody
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Festen, E.A., et al. Am. J. Gastroenterol. 105(2):395-402(2010)
Biederer, T. Genomics 87(1):139-150(2006)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
47554
NCBI Official Full Name
cell adhesion molecule 2 isoform 1
NCBI Official Synonym Full Names
cell adhesion molecule 2
NCBI Official Symbol
CADM2
NCBI Official Synonym Symbols
NECL3; IGSF4D; Necl-3; synCAM2; SynCAM 2
NCBI Protein Information
cell adhesion molecule 2
UniProt Protein Name
Cell adhesion molecule 2
Protein Family
UniProt Gene Name
CADM2
UniProt Synonym Gene Names
IGSF4D; NECL3; IgSF4D; NECL-3; SynCAM 2
UniProt Entry Name
CADM2_HUMAN

NCBI Description

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Description

CADM2: Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p12.1

Cellular Component: axon; cytoplasm; integral to membrane; plasma membrane; synapse; cell junction

Biological Process: intercellular junction assembly and maintenance; brain development; cell adhesion

Research Articles on CADM2

Similar Products

Product Notes

The CADM2 cadm2 (Catalog #AAA9202084) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 50-76. The CADM2 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CADM2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the CADM2 cadm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CADM2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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