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Western Blot (WB) (Western blot analysis of CACNG5 antibody (C-term) in K562 cell line lysates (35ug/lane). CACNG5 (arrow) was detected using the purified Pab.)

Rabbit CACNG5 Polyclonal Antibody | anti-CACNG5 antibody

CACNG5 Antibody (C-term)

Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Applications
Western Blot, ELISA, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CACNG5; Polyclonal Antibody; CACNG5 Antibody (C-term); Voltage-dependent calcium channel gamma-5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; Transmembrane AMPAR regulatory protein gamma-5; TARP gamma-5; anti-CACNG5 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This CACNG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the C-terminal region of human CACNG5.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
192-220
Sequence Length
275
Applicable Applications for anti-CACNG5 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of CACNG5 antibody (C-term) in K562 cell line lysates (35ug/lane). CACNG5 (arrow) was detected using the purified Pab.)

Western Blot (WB) (Western blot analysis of CACNG5 antibody (C-term) in K562 cell line lysates (35ug/lane). CACNG5 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human brain tissue reacted with CACNG5 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Immunohistochemistry (IHC) (Formalin-fixed and paraffin-embedded human brain tissue reacted with CACNG5 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of K562 cells using CACNG5 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Flow Cytometry (FC/FACS) (Flow cytometric analysis of K562 cells using CACNG5 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Related Product Information for anti-CACNG5 antibody
L-type calcium channels are composed of five subunits. The protein CACNG5 represents one of these subunits, gamma, and is one of several gamma subunit proteins. It is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state.
Product Categories/Family for anti-CACNG5 antibody
References
Chu,P.J., Gene 280 (1-2), 37-48 (2001)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30903
NCBI Official Full Name
voltage-dependent calcium channel gamma-5 subunit
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 5
NCBI Official Symbol
CACNG5
NCBI Protein Information
voltage-dependent calcium channel gamma-5 subunit
UniProt Protein Name
Voltage-dependent calcium channel gamma-5 subunit
UniProt Gene Name
CACNG5
UniProt Synonym Gene Names
TARP gamma-5
UniProt Entry Name
CCG5_HUMAN

NCBI Description

The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]

Uniprot Description

CACNG5: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 17q24

Cellular Component: postsynaptic membrane; postsynaptic density; cell junction

Molecular Function: voltage-gated calcium channel activity; ion transmembrane transporter activity

Biological Process: transport

Research Articles on CACNG5

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Product Notes

The CACNG5 cacng5 (Catalog #AAA9211306) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 192-220. The CACNG5 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's CACNG5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the CACNG5 cacng5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CACNG5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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