Testing Data
(Sample (30 ug of whole cell lysate) A: A5495% SDS PAGE Primary antibody diluted at 1: 1000)
Rabbit anti-Human CACNA1B Polyclonal Antibody | anti-CACNA1B antibody
CACNA1B antibody
Immunofluorescence: 1:100-1:200
Testing Data
(Sample (30 ug of whole cell lysate) A: A5495% SDS PAGE Primary antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: A5495% SDS PAGE Primary antibody diluted at 1: 1000)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A549, using CACNA1B antibody at 1: 500 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A549, using CACNA1B antibody at 1: 500 dilution.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Description
CACNA1B: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1B subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: cell soma; dendrite; plasma membrane; voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity; protein C-terminus binding; protein binding; high voltage-gated calcium channel activity; calcium ion binding; ATP binding
Biological Process: membrane depolarization; synaptic transmission; transport; neurotransmitter secretion; regulation of blood pressure; locomotory behavior; response to pain; regulation of calcium ion transport; regulation of heart contraction
Disease: Dystonia 23
Research Articles on CACNA1B
Similar Products
Product Notes
The CACNA1B cacna1b (Catalog #AAA9406733) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CACNA1B antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CACNA1B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Western blotting: 1:500-1:3000 Immunofluorescence: 1:100-1:200. Researchers should empirically determine the suitability of the CACNA1B cacna1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CACNA1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
