Western Blot (WB)
(WB Suggested Anti-CABP1 AntibodyTitration: 1.0 ug/mlPositive Control: Jurkat Whole Cell)
Rabbit CABP1 Polyclonal Antibody | anti-CABP1 antibody
CABP1 antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-CABP1 AntibodyTitration: 1.0 ug/mlPositive Control: Jurkat Whole Cell)
Western Blot (WB)
(WB Suggested Anti-CABP1 AntibodyTitration: 1.0 ug/mlPositive Control: Jurkat Whole Cell)
Target Description: The product of this gene belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of this gene was only detected in retina and brain. Study of the mouse homolog demonstrated that groups of cells expressing this protein are located in the center or inner border of the inner unclear layer of retina. Three alternatively spliced variants encoding different isoforms have been described.
NCBI and Uniprot Product Information
NCBI Description
Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold; Calcium-binding; Inhibitor
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: extracellular space; internal side of plasma membrane; protein complex; dendrite; postsynaptic density; cell cortex; cytosol; Golgi membrane; postsynaptic membrane; cytoskeleton; cell soma; perinuclear region of cytoplasm; plasma membrane; cell junction; nucleus
Molecular Function: enzyme inhibitor activity; protein domain specific binding; protein binding; protein homodimerization activity; nuclear localization sequence binding; type 3 metabotropic glutamate receptor binding; calcium ion binding; calcium-dependent protein binding
Biological Process: negative regulation of catalytic activity; negative regulation of protein import into nucleus
Research Articles on CABP1
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Product Notes
The CABP1 cabp1 (Catalog #AAA3216217) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CABP1 antibody - N-terminal region reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CABP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the CABP1 cabp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: TPQSSGDPSS RRPLCRPAPR EEGARGSQRV LPQAHCRPRE ALPAAASRPS. It is sometimes possible for the material contained within the vial of "CABP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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