Western Blot (WB)
(Western Blot analysis of CAB39 expression in transfected 293T cell line by CAB39 polyclonal antibody. Lane 1: CAB39 transfected lysate (39.9kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human CAB39 Polyclonal Antibody | anti-CAB39 antibody
CAB39 (Calcium-binding Protein 39, Protein Mo25, CAB39, MO25, CGI-66, FLJ22682) APC
Gene Names
CAB39; MO25; CGI-66
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
CAB39; Polyclonal Antibody; CAB39 (Calcium-binding Protein 39; Protein Mo25; MO25; CGI-66; FLJ22682) APC; anti-CAB39 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human CAB39.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Applicable Applications for anti-CAB39 antibody
Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Full length human CAB39, aa1-341 (NP_057373.1).
Immunogen Sequence
MPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVSKNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIFNNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKIILWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLKRPAQQEA
Conjugate
APC
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of CAB39 expression in transfected 293T cell line by CAB39 polyclonal antibody. Lane 1: CAB39 transfected lysate (39.9kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of CAB39 expression in transfected 293T cell line by CAB39 polyclonal antibody. Lane 1: CAB39 transfected lysate (39.9kD). Lane 2: Non-transfected lysate.)
Related Product Information for anti-CAB39 antibody
CAB39 together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). CAB39 binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity. Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-CAB39 complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-CAB39 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-CAB39 during skeletal muscle contraction may be regulated by allosteric mechanisms.
Product Categories/Family for anti-CAB39 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~63 kDa
NCBI Official Full Name
Homo sapiens calcium binding protein 39 (CAB39), transcript variant 1, mRNA
NCBI Official Synonym Full Names
calcium binding protein 39
NCBI Official Symbol
CAB39
NCBI Official Synonym Symbols
MO25; CGI-66
NCBI Protein Information
calcium-binding protein 39; MO25alpha
UniProt Protein Name
Calcium-binding protein 39
Protein Family
UniProt Gene Name
CAB39
UniProt Synonym Gene Names
MO25
UniProt Entry Name
CAB39_HUMAN
Uniprot Description
CAB39: a adaptor protein that, together with STRAD-alpha, forms a regulatory complex capable of stimulating the activity of LKB1. Interacts with Mst4, which plays an essential role in brush border formation in intestinal epithelial cells.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: cytosol
Molecular Function: protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; kinase binding; protein kinase activator activity
Biological Process: protein heterooligomerization; activation of protein kinase activity; insulin receptor signaling pathway; cell cycle arrest; protein amino acid phosphorylation; positive regulation of peptidyl-serine phosphorylation
Research Articles on CAB39
Similar Products
Product Notes
The CAB39 cab39 (Catalog #AAA6371828) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CAB39 (Calcium-binding Protein 39, Protein Mo25, CAB39, MO25, CGI-66, FLJ22682) APC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CAB39 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CAB39 cab39 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CAB39, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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