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Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin- embedded human colon cancer tissue using anti-BMP11 rabbit polyclonal antibody.)

Rabbit BMP11 Polyclonal Antibody | anti-BMP11 antibody

BMP11 Antibody

Gene Names
GDF11; BMP11; BMP-11
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunocytochemistry, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
ProA affinity purified.
Synonyms
BMP11; Polyclonal Antibody; BMP11 Antibody; BMP 11 antibody; BMP-11 antibody; BMP11 antibody; Bone morphogenetic protein 11 antibody; GDF 11 antibody; GDF-11 antibody; Gdf11 antibody; GDF11_HUMAN antibody; Growth differentiation factor 11 antibody; Growth/differentiation factor 11 antibody; anti-BMP11 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
ProA affinity purified.
Form/Format
1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-BMP11 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes
IHC: 1:50-1:200
ICC: 1:50-1:200
FC/FACS: 1:50-1:100
Immunogen
Recombinant protein
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin- embedded human colon cancer tissue using anti-BMP11 rabbit polyclonal antibody.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin- embedded human colon cancer tissue using anti-BMP11 rabbit polyclonal antibody.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-BMP11 rabbit polyclonal antibody.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-BMP11 rabbit polyclonal antibody.)

Immunocytochemistry (ICC)

(Immunocytochemical staining of Hela cells using anti-BMP11 rabbit polyclonal antibody.)

Immunocytochemistry (ICC) (Immunocytochemical staining of Hela cells using anti-BMP11 rabbit polyclonal antibody.)

Immunocytochemistry (ICC)

(Immunocytochemical staining of SW480 cells using anti-BMP11 rabbit polyclonal antibody.)

Immunocytochemistry (ICC) (Immunocytochemical staining of SW480 cells using anti-BMP11 rabbit polyclonal antibody.)

Flow Cytometry (FC/FACS)

(Flow cytometric analysis of HepG2 cells with BMP11 antibody at 1/100 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary antibody.)

Flow Cytometry (FC/FACS) (Flow cytometric analysis of HepG2 cells with BMP11 antibody at 1/100 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated Goat anti rabbit IgG was used as the secondary antibody.)
Related Product Information for anti-BMP11 antibody
GDF-11, a member of the Transforming Growth Factor (TGF) Beta superfamily, controls anterior/posterior patterning of the axial skeleton, regulates organogenesis by controlling expression of Gdnf, contributes to the control of Hox gene expression, and induces phosphorylation of Smad2. In addition, GDF-11 mediates signaling of Nodal during left-right patterning and development of head structures and inhibits generation of new neurons by neuronal progenitors in the olfactory epithelium.
Product Categories/Family for anti-BMP11 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45,091 Da
NCBI Official Full Name
growth/differentiation factor 11
NCBI Official Synonym Full Names
growth differentiation factor 11
NCBI Official Symbol
GDF11
NCBI Official Synonym Symbols
BMP11; BMP-11
NCBI Protein Information
growth/differentiation factor 11; GDF-11; bone morphogenetic protein 11
UniProt Protein Name
Growth/differentiation factor 11
UniProt Gene Name
GDF11
UniProt Synonym Gene Names
BMP11; GDF-11; BMP-11
UniProt Entry Name
GDF11_HUMAN

NCBI Description

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

Uniprot Description

GDF11: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: nervous system development; cell maturation; palate development; regulation of apoptosis; negative regulation of cell proliferation; negative regulation of cell differentiation; camera-type eye morphogenesis; spinal cord anterior/posterior patterning; ureteric bud development; regulation of MAPKKK cascade; pancreas development; mesoderm development; metanephros development; skeletal development; cell development; growth

Research Articles on BMP11

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Product Notes

The BMP11 gdf11 (Catalog #AAA9435095) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BMP11 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's BMP11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). IHC: 1:50-1:200 ICC: 1:50-1:200 FC/FACS: 1:50-1:100. Researchers should empirically determine the suitability of the BMP11 gdf11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BMP11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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