Western Blot (WB)
(Western Blot analysis of human prostate using MBS616492. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.)
Rabbit BIRC2 Polyclonal Antibody | anti-BIRC2 antibody
BIRC2 (Baculoviral IAP Repeat-containing Protein 2, C-IAP1, IAP Homolog B, Inhibitor of Apoptosis Protein 2, IAP-2, hIAP-2, hIAP2, RING Finger Protein 48, TNFR2-TRAF-signaling Complex Protein 2, API1, IAP2, MIHB, RNF48)
Gene Names
BIRC2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; BIRC2
Reactivity
Canine, Gerbil, Mouse and Rat.
Applications
Western Blot, Immunoprecipitation, Immunohistochemistry
Purity
Serum
Synonyms
BIRC2; Polyclonal Antibody; BIRC2 (Baculoviral IAP Repeat-containing Protein 2; C-IAP1; IAP Homolog B; Inhibitor of Apoptosis Protein 2; IAP-2; hIAP-2; hIAP2; RING Finger Protein 48; TNFR2-TRAF-signaling Complex Protein 2; API1; IAP2; MIHB; RNF48); Anti -BIRC2 (Baculoviral IAP Repeat-containing Protein 2; anti-BIRC2 antibody
Host
Rabbit
Reactivity
Canine, Gerbil, Mouse and Rat.
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human BIRC2.
Purity/Purification
Serum
Form/Format
Supplied as a liquid, 0.05% sodium azide.
Applicable Applications for anti-BIRC2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC). Other applications not tested.
Application Notes
Western Blot: 1:1000-1:2000
Immunohistochemistry (FFPE & Frozen) : 1:100-1:5000
Immunoprecipitation: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Immunohistochemistry (FFPE & Frozen) : 1:100-1:5000
Immunoprecipitation: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Immunogen
Recombinant corresponding to full-length human BIRC2
Positive Control
Human prostate, CIAP-1/HIAP-2 Knockout HeLa cell lysate
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of human prostate using MBS616492. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.)
Western Blot (WB)
(Western Blot analysis of human prostate using MBS616492. PBH (benign prostate hyperplasia), PIN (prostate intraepithelial neoplasia). Elevated levels of cIAP1 were seen in certain cases of BPH/PIN and prostate cancer compared to normal prostate.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate using MBS616492 (1:2000). A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of formalin-fixed, paraffin-embedded human prostate using MBS616492 (1:2000). A, normal prostate. B, prostate intraepithelial neoplasia (PIN). PIN is a premalignant proliferation arising within the prostate. C, prostate cancer. Hematoxylin-eosin counterstain. Increased cIAP1 expression is PIN and in prostate cancer compared to normal prostate.)
Related Product Information for anti-BIRC2 antibody
cIAP1 (HIAP2, MIHB) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and -independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs, including cIAP2, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination. Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. The IAPs, including cIAP1, have widespread tissue protein expression, with expression levels and subcellular localization patterns differing depending on the cell lineage (see Vischioni et al. 2005 for a comprehensive study). Recognizes cIAP1, human cIAP1 is a 618aa protein.
Product Categories/Family for anti-BIRC2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
baculoviral IAP repeat-containing protein 2 [Homo sapiens]
NCBI Official Synonym Full Names
baculoviral IAP repeat-containing 2
NCBI Official Symbol
BIRC2
NCBI Official Synonym Symbols
API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1; BIRC2
NCBI Protein Information
baculoviral IAP repeat-containing protein 2; IAP-2; IAP homolog B; apoptosis inhibitor 1; RING finger protein 48; inhibitor of apoptosis protein 2; NFR2-TRAF signalling complex protein; TNFR2-TRAF-signaling complex protein 2
UniProt Protein Name
Baculoviral IAP repeat-containing protein 2
Protein Family
UniProt Gene Name
BIRC2
UniProt Synonym Gene Names
API1; IAP2; MIHB; RNF48
UniProt Entry Name
BIRC2_HUMAN
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Product Notes
The BIRC2 birc2 (Catalog #AAA616492) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BIRC2 (Baculoviral IAP Repeat-containing Protein 2, C-IAP1, IAP Homolog B, Inhibitor of Apoptosis Protein 2, IAP-2, hIAP-2, hIAP2, RING Finger Protein 48, TNFR2-TRAF-signaling Complex Protein 2, API1, IAP2, MIHB, RNF48) reacts with Canine, Gerbil, Mouse and Rat. and may cross-react with other species as described in the data sheet. AAA Biotech's BIRC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC). Other applications not tested. Western Blot: 1:1000-1:2000 Immunohistochemistry (FFPE & Frozen) : 1:100-1:5000 Immunoprecipitation: 1:50-1:200 Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the BIRC2 birc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BIRC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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