Rabbit anti-Human, Mouse BIRC2 Polyclonal Antibody | anti-BIRC2 antibody

BIRC2 Polyclonal Antibody

Cat. Num. AAA3007119

• Gene Names: BIRC2; API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: BIRC2; Polyclonal Antibody; BIRC2 Polyclonal Antibody; Baculoviral IAP repeat-containing protein 2; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; RING finger protein 48; TNFR2-TRAF-signaling complex protein 2; API1; IAP2; MIHB; RNF48; anti-BIRC2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: BIRC2 polyclonal antibody detects endogenous levels of BIRC2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 618

• Applicable Applications for anti-BIRC2 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IF: 1:50-1:200
• Immunogen: Recombinant full length Human BIRC2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of BIRC2 polyclonal antibody in extracts from Jurkat, Hela and HT29 cells.)

Immunofluorescence (IF)

(Immunofluorescence analysis of Hela cells, using BIRC2 polyclonal antibody)

Related Product Information for anti-BIRC2 antibody

Three mammalian homologs of baculovirus p35, designated MIHA (mammalian IAP homolog A), MIHB and MIHC have been described. These three mammalian inhibitor of apoptosis proteins (IAPs) are designated XIAP, c-IAP1 and c-IAP2, respectively. XIAP, c-IAP1 and c-IAP2 share an N-terminal baculovirus IAP repeat (BIR) motif and a C-terminal RING finger. Although c-IAP1 and c-IAP2 do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. The interaction between the TRAF1/TRAF2 heterocomplexes and c-IAPs is dependent on a functional BIR motif.

NCBI and Uniprot Product Information

• NCBI GI #: 4502141
• NCBI GeneID: 329
• NCBI Accession #: NP_001157.1
• NCBI GenBank Nucleotide #: NP_001157.1
• UniProt Accession #: Q13490
• Molecular Weight: ~ 70kDa
• NCBI Official Full Name: baculoviral IAP repeat-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: baculoviral IAP repeat containing 2
• NCBI Official Symbol: BIRC2
• NCBI Official Synonym Symbols: API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
• NCBI Protein Information: baculoviral IAP repeat-containing protein 2
• UniProt Protein Name: Baculoviral IAP repeat-containing protein 2
• Protein Family: Baculoviral IAP repeat-containing protein
• UniProt Gene Name: BIRC2
• UniProt Synonym Gene Names: API1; IAP2; MIHB; RNF48; IAP-2; hIAP-2; hIAP2
• UniProt Entry Name: BIRC2_HUMAN

NCBI Description

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]