Rabbit anti-Human, Mouse Bcr Polyclonal Antibody | anti-BCR antibody

Bcr Antibody

Cat. Num. AAA9503759

• Gene Names: BCR; ALL; CML; PHL; BCR1; D22S11; D22S662
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Synonyms: Bcr; Polyclonal Antibody; Bcr Antibody; BCR; BCR protein; BCR1; Breakpoint cluster region protein; anti-BCR antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Bcr Antibody detects endogenous levels of total Bcr protein.
• Purity/Purification: Purified from rabbit antiserum by affinity-chromatography using immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1,227

• Applicable Applications for anti-BCR antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:50~1:100; ELISA: 1:1000
• Target Modification: Unmodified/Total
• Immunogen: The antiserum was produced against synthesized peptide derived from human Bcr.
• Immunogen Range: 331-380
• Preparation and Storage: Stable at -20 degree C for at least 1 year.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Bcr Antibody. The picture on the right is blocked with the synthesized peptide.)

NCBI and Uniprot Product Information

• NCBI GI #: 82546843
• NCBI GeneID: 613
• NCBI Accession #: NP_004318.3
• NCBI GenBank Nucleotide #: NM_004327.3
• UniProt Accession #: P11274; P78501; Q12842; Q4LE80; Q6NZI3
• Molecular Weight: 142 kDa
• NCBI Official Full Name: breakpoint cluster region protein isoform 1
• NCBI Official Synonym Full Names: BCR, RhoGEF and GTPase activating protein
• NCBI Official Symbol: BCR
• NCBI Official Synonym Symbols: ALL; CML; PHL; BCR1; D22S11; D22S662
• NCBI Protein Information: breakpoint cluster region protein
• UniProt Protein Name: Breakpoint cluster region protein
• Protein Family: Bicyclomycin resistance protein
• UniProt Gene Name: BCR
• UniProt Synonym Gene Names: BCR1; D22S11

NCBI Description

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.