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Western Blot (WB) (Western blot analysis of Bcl-xL expression in Jurkat (Lane 1 & 2), mouse small intestine (Lane 3) and rat kidney lysates (Lane 4).)

Rabbit Bcl-xL Polyclonal Antibody | anti-Bcl-xL antibody

Bcl-xL Antibody

Gene Names
BCL2L1; BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S
Applications
Immunoprecipitation, Western Blot
Purity
Affinity Chromatography
Synonyms
Bcl-xL; Polyclonal Antibody; Bcl-xL Antibody; Rabbit Polyclonal Bcl-xL Antibody; Polyclonal Bcl-xL antibody; anti-Bcl-xL antibody; Bcl-xS antibody; Bcl-xL antibody; BCL2L1 antibody; BCL2-like 1 protein antibody
Ordering
For Research Use Only!
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Chromatography
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% Glycerol, 0.5% BSA, 0.01% Thimerosal
Concentration
500 ug/ml (varies by lot)
Sequence Length
233
Applicable Applications for anti-Bcl-xL antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes
WB: 0.5-4 ug/ml
Immunogen
Bcl-xL antibody was raised in Rabbit using synthetic peptide surrounding amino acid 56 of human Bcl-xL as the immunogen.
Cross-Reactivity
Human, Mouse, Rat
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of Bcl-xL expression in Jurkat (Lane 1 & 2), mouse small intestine (Lane 3) and rat kidney lysates (Lane 4).)

Western Blot (WB) (Western blot analysis of Bcl-xL expression in Jurkat (Lane 1 & 2), mouse small intestine (Lane 3) and rat kidney lysates (Lane 4).)
Related Product Information for anti-Bcl-xL antibody
Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis through two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.
Product Categories/Family for anti-Bcl-xL antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
598
NCBI Official Full Name
bcl-xL
NCBI Official Synonym Full Names
BCL2 like 1
NCBI Official Symbol
BCL2L1
NCBI Official Synonym Symbols
BCLX; BCL2L; Bcl-X; PPP1R52; BCL-XL/S
NCBI Protein Information
bcl-2-like protein 1

NCBI Description

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]

Research Articles on Bcl-xL

Similar Products

Product Notes

The Bcl-xL (Catalog #AAA5311257) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Bcl-xL can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB). WB: 0.5-4 ug/ml. Researchers should empirically determine the suitability of the Bcl-xL for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Bcl-xL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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