Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using BAZ2A antibody. )
Rabbit anti-Human BAZ2A Polyclonal Antibody | anti-BAZ2A antibody
BAZ2A Antibody
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using BAZ2A antibody. )
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using BAZ2A antibody. )
NCBI and Uniprot Product Information
Uniprot Description
BMZF-2: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA- binding is required for heterochromatin formation and rDNA silencing. Belongs to the WAL family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleolus; Transcription regulation; DNA-binding
Chromosomal Location of Human Ortholog: 12q13.3
Cellular Component: chromatin silencing complex; nucleolus
Molecular Function: ligand-dependent nuclear receptor binding; protein binding; DNA binding; zinc ion binding; RNA binding
Biological Process: chromatin remodeling; chromatin silencing at rDNA; transcription, DNA-dependent; regulation of transcription, DNA-dependent; negative regulation of gene expression, epigenetic; DNA methylation; histone deacetylation; gene expression; regulation of gene expression, epigenetic; histone H3-K9 methylation
Research Articles on BAZ2A
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Product Notes
The BAZ2A baz2a (Catalog #AAA7131227) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The BAZ2A Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's BAZ2A can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB: 1:500-1:3000. Researchers should empirically determine the suitability of the BAZ2A baz2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BAZ2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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