Rabbit ATP1A3 Polyclonal Antibody | anti-ATP1A3 antibody

Anti-ATP1A3 Antibody, Rabbit Polyclonal

Cat. Num. AAA8102370

• Gene Names: Atp1a3; Atpa-2
• Reactivity: Mouse; Predicted to React with: Human, Rat (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: ATP1A3; Polyclonal Antibody; Anti-ATP1A3 Antibody; Rabbit Polyclonal; ATP1A3 Antibody; Rabbit PAb; Antigen Affinity Purified; anti-ATP1A3 antibody

• Host: Rabbit
• Reactivity: Mouse; Predicted to React with: Human, Rat (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Mouse ATP1A3
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-ATP1A3 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the N-terminus of the Mouse ATP1A3
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Mouse ATP1A3, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse Atp1a3 in mouse brain with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-ATP1A3 antibody

ATP1A3 mutations have now been recognized in infants, children, and adults presenting with a diverse group of neurological phenotypes, including rapid-onset dystonia-parkinsonism, alternating hemiplegia of childhood, and most recently, cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss syndrome. ATP1A3 has also been associated with CAPOS syndrome (cerebellar ataxia, areflexia, pes cavus, optic atrophy, and sensorineural hearing loss).

NCBI and Uniprot Product Information

• NCBI GI #: 27552786
• NCBI GeneID: 232975
• UniProt Accession #: Q6PIC6
• Molecular Weight: 111,692 Da
• NCBI Official Full Name: Atp1a3 protein
• NCBI Official Synonym Full Names: ATPase, Na+/K+ transporting, alpha 3 polypeptide
• NCBI Official Symbol: Atp1a3
• NCBI Official Synonym Symbols: Atpa-2
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-3
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: Atp1a3
• UniProt Synonym Gene Names: Na(+)/K(+) ATPase alpha-3 subunit
• UniProt Entry Name: AT1A3_MOUSE

Uniprot Description

Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients

By similarity.

Catalytic activity: ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Subunit structure: Composed of three subunits: alpha (catalytic), beta and gamma

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity.

Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]