Rabbit anti-Human ATP1A3 Polyclonal Antibody | anti-Atp1a3 antibody

ATP1A3, ID (ATP1A3, Sodium/potassium-transporting ATPase subunit alpha-3, Na(+)/K(+) ATPase alpha(III) subunit, Sodium pump subunit alpha-3)

Cat. Num. AAA6009114

• Gene Names: Atp1a3; Atpa-2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ATP1A3; Polyclonal Antibody; ID (ATP1A3; Sodium/potassium-transporting ATPase subunit alpha-3; Na(+)/K(+) ATPase alpha(III) subunit; Sodium pump subunit alpha-3); Anti -ATP1A3; anti-Atp1a3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-Atp1a3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: ATP1A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-833 amino acids from the Central region of human ATP1A3.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ATP1A3 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ATP1A3 antibody detected the ATP1A3 protein (arrow).)

Related Product Information for anti-Atp1a3 antibody

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit.

Product Categories/Family for anti-Atp1a3 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 27552786
• NCBI GeneID: 232975
• UniProt Accession #: Q6PIC6
• Molecular Weight: 111,692 Da
• NCBI Official Full Name: Atp1a3 protein
• NCBI Official Synonym Full Names: ATPase, Na+/K+ transporting, alpha 3 polypeptide
• NCBI Official Symbol: Atp1a3
• NCBI Official Synonym Symbols: Atpa-2
• NCBI Protein Information: sodium/potassium-transporting ATPase subunit alpha-3; sodium pump subunit alpha-3; Na(+)/K(+) ATPase alpha-3 subunit; Na(+)/K(+) ATPase alpha(III) subunit
• UniProt Protein Name: Sodium/potassium-transporting ATPase subunit alpha-3
• Protein Family: Sodium/potassium-transporting ATPase
• UniProt Gene Name: Atp1a3
• UniProt Synonym Gene Names: Na(+)/K(+) ATPase alpha-3 subunit
• UniProt Entry Name: AT1A3_MOUSE

Uniprot Description

ATP1A3: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Defects in ATP1A3 are the cause of dystonia type 12 (DYT12); also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant dystonia- parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT12 patients develop dystonia and parkinsonism between 15 and 45 years of age. The disease is characterized by an unusually rapid evolution of signs and symptoms. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.

Protein type: Hydrolase; Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Transporter; Transporter, ion channel; EC 3.6.3.9

Cellular Component: Golgi apparatus; endoplasmic reticulum; integral to membrane; membrane; axon; cytoplasm; plasma membrane; synapse; nucleus; sodium:potassium-exchanging ATPase complex; myelin sheath; sarcolemma; vesicle

Molecular Function: heparan sulfate proteoglycan binding; hydrolase activity; chaperone binding; metal ion binding; nucleotide binding; sodium:potassium-exchanging ATPase activity; D1 dopamine receptor binding; ATP binding

Biological Process: response to drug; cellular sodium ion homeostasis; adult locomotory behavior; sodium ion transport; cellular potassium ion homeostasis; memory; potassium ion import; ionotropic glutamate receptor signaling pathway; transport; visual learning; ion transport; potassium ion transport; cardiac muscle contraction