Rabbit ATP6V0A2 Polyclonal Antibody | anti-ATP6V0A2 antibody

Anti-ATP6V0A2 Antibody, Rabbit Polyclonal

Cat. Num. AAA8103591

• Gene Names: ATP6V0A2; A2; RTF; TJ6; WSS; ARCL; J6B7; STV1; TJ6M; TJ6S; VPH1; ARCL2A; ATP6A2; ATP6N1D
• Reactivity: Human; Predicted to React with: Bovin (Species predicted to react based on 100% sequence homology)
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: ATP6V0A2; Polyclonal Antibody; Anti-ATP6V0A2 Antibody; Rabbit Polyclonal; ATP6V0A2 Antibody; Rabbit PAb; Antigen Affinity Purified; ATPase; H+ transporting; lysosomal V0 subunit a2; Anti-A2 Antibody; Anti-ARCL Antibody; Anti-ARCL2A Antibody; Anti-ATP6A2 Antibody; Anti-ATP6N1D Antibody; Anti-J6B7 Antibody; Anti-RTF Antibody; Anti-STV1 Antibody; Anti-TJ6 Antibody; Anti-TJ6M Antibody; Anti-TJ6S Antibody; Anti-VPH1 Antibody; Anti-WSS Antibody; anti-ATP6V0A2 antibody

• Host: Rabbit
• Reactivity: Human; Predicted to React with: Bovin (Species predicted to react based on 100% sequence homology)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human ATP6V0A2
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-ATP6V0A2 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:200-1:1000
• Immunogen: A synthetic peptide corresponding to the center region of the Human ATP6V0A2
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human ATP6V0A2, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human ATP6V0A2 in human kidney with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-ATP6V0A2 antibody

The loss-of-function mutations in ATP6V0A2, encoding the a2 subunit of the V-type H+ ATPase, in several families with autosomal recessive cutis laxa type II or wrinkly skin syndrome. The mutations result in abnormal glycosylation of serum proteins (CDG-II) and cause an impairment of Golgi trafficking in fibroblasts from affected individuals. Autosomal recessive cutis laxa type 2 (ARCL2), a syndrome of growth and developmental delay and redundant, inelastic skin, is caused by mutations in the a2 subunit of the vesicular ATPase H+-pump (ATP6V0A2). Loss-of-function mutations in ATP6V0A2 lead to TE aggregation in the Golgi, impaired clearance of TE aggregates and increased apoptosis of elastogenic cells.

NCBI and Uniprot Product Information

• NCBI GI #: 42741679
• NCBI GeneID: 23545
• NCBI Accession #: NP_036595
• NCBI GenBank Nucleotide #: NM_012463
• UniProt Accession #: Q9Y487; Q6NUM0; A8K026
• Molecular Weight: 98,082 Da
• NCBI Official Full Name: V-type proton ATPase 116 kDa subunit a isoform 2
• NCBI Official Synonym Full Names: ATPase, H+ transporting, lysosomal V0 subunit a2
• NCBI Official Symbol: ATP6V0A2
• NCBI Official Synonym Symbols: A2; RTF; TJ6; WSS; ARCL; J6B7; STV1; TJ6M; TJ6S; VPH1; ARCL2A; ATP6A2; ATP6N1D
• NCBI Protein Information: V-type proton ATPase 116 kDa subunit a isoform 2; A2V-ATPase; lysosomal H(+)-transporting ATPase V0 subunit a2; regeneration and tolerance factor; v-ATPase 116 kDa; v-type proton ATPase 116 kDa subunit a; vacuolar proton translocating ATPase 116 kDa subun
• UniProt Protein Name: V-type proton ATPase 116 kDa subunit a isoform 2
• Protein Family: V-type proton ATPase
• UniProt Gene Name: ATP6V0A2
• UniProt Synonym Gene Names: V-ATPase 116 kDa isoform a2
• UniProt Entry Name: VPP2_HUMAN