Rabbit anti-Human ATAD2 Polyclonal Antibody | anti-ATAD2 antibody
ATAD2 Antibody
Gene Names
ATAD2; ANCCA; CT137; PRO2000
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
ATAD2; Polyclonal Antibody; ATAD2 Antibody; AAA nuclear coregulator cancer-associated protein; AAA nuclear coregulator; cancer-associated; ANCCA; Atad2; ATAD2_HUMAN; ATPase family AAA domain containing 2; ATPase family AAA domain containing protein 2; ATPase family AAA domain-containing protein 2; CT137; DKFZp667N1320; L16; MGC131938; MGC142216; MGC29843; MGC5254; PRO2000; anti-ATAD2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
ATAD2 Antibody detects endogenous levels of ATAD2.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-ATAD2 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human ATAD2.
Conjugation
Unconjugated
Similarity
Belongs to the AAA ATPase family.
Subunit Structure
Interacts with ESR1 and NCOA3 and these interactions are enhanced by estradiol. Interacts with acetylated lysine residues on histone H1.4, H2A, H2B and H3 (in vitro).
Tissue Specificity
Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
Function
May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,986 Da
NCBI Official Full Name
ATPase family AAA domain-containing protein 2
NCBI Official Synonym Full Names
ATPase family, AAA domain containing 2
NCBI Official Symbol
ATAD2
NCBI Official Synonym Symbols
ANCCA; CT137; PRO2000
NCBI Protein Information
ATPase family AAA domain-containing protein 2
UniProt Protein Name
ATPase family AAA domain-containing protein 2
Protein Family
UniProt Gene Name
ATAD2
UniProt Synonym Gene Names
L16; PRO2000; ANCCA
UniProt Entry Name
ATAD2_HUMAN
NCBI Description
A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]
Research Articles on ATAD2
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Product Notes
The ATAD2 atad2 (Catalog #AAA9629748) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATAD2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ATAD2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the ATAD2 atad2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ATAD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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