Testing Data #1
(staining of formalin fixed, paraffin embedded huan liver with Rabbit anti Human PPAR aplha (MBS222910))
Rabbit PPAR ALPHA Polyclonal Antibody | anti-PPAR ALPHA antibody
RABBIT ANTI PPAR ALPHA
Peroxisome proliferator-activated receptors are vital in the regulation of cellular differentiation, development and metabolism. PPARA is also the target of hypolipidemic fibrates, a class of drugs used in cholesterol disorders.
PPARA alpha is expressed primarily in the liver, kidney, heart and skeletal muscle and is involved in the regulation of beta-oxidation of fatty acids.
Purified IgG - liquid
Immunohistology - Paraffin: Maximum Dilution: 20ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Maximum Dilution: 1/500
Histology Positive Control Tissue
Shelf Life: 18 months from date of despatch.
Testing Data #1
(staining of formalin fixed, paraffin embedded huan liver with Rabbit anti Human PPAR aplha (MBS222910))
Testing Data #1
(staining of formalin fixed, paraffin embedded huan liver with Rabbit anti Human PPAR aplha (MBS222910))
NCBI and Uniprot Product Information
Uniprot Description
PPAR-alpha: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily.
Protein type: Nuclear receptor; DNA-binding
Cellular Component: nucleus
Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; metal ion binding; receptor activity; drug binding; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; protein heterodimerization activity; sequence-specific DNA binding; protein complex binding; steroid hormone receptor activity; lipid binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; epidermis development; wound healing; positive regulation of transcription, DNA-dependent; rhythmic process; behavioral response to nicotine; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; regulation of fatty acid metabolic process; negative regulation of blood pressure; circadian regulation of gene expression; negative regulation of protein binding; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; glucose metabolic process; lipoprotein metabolic process; regulation of circadian rhythm; regulation of gene expression; positive regulation of fatty acid oxidation; response to hypoxia; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process
Research Articles on PPAR ALPHA
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Product Notes
The PPAR ALPHA ppara (Catalog #AAA222910) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RABBIT ANTI PPAR ALPHA reacts with Chimpanzee, Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's PPAR ALPHA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB). ELISA: Maximum Dilution: 1/8000; Immunohistology - Paraffin: Maximum Dilution: 20ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. Western Blotting: Maximum Dilution: 1/500. Researchers should empirically determine the suitability of the PPAR ALPHA ppara for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPAR ALPHA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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