Rabbit anti-Human, Rat ASIC2 Polyclonal Antibody | anti-ACCN1 antibody

ASIC2 (Acid Sensitive Ion Channel 2, BNaC1, Brain Sodium Channel 1, BNC1, MDEG1, Mammalian Degenerin1, Amiloride-Sensitive Neuronal Cation Channel 1, Accn1)

Cat. Num. AAA610771

• Gene Names: ACCN1; ACCN; BNC1; MDEG; ASIC2; BNaC1; ASIC2a; hBNaC1
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: ASIC2; Polyclonal Antibody; ASIC2 (Acid Sensitive Ion Channel 2; BNaC1; Brain Sodium Channel 1; BNC1; MDEG1; Mammalian Degenerin1; Amiloride-Sensitive Neuronal Cation Channel 1; Accn1); Anti -ASIC2 (Acid Sensitive Ion Channel 2; anti-ACCN1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Acid Sensitive Ion Channel 2. Does not recognize ASIC2b. Species crossreactivity
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 1% BSA, 5% sucrose, 0.025% sodium azide before the addition of glycerol to 40%.

• Applicable Applications for anti-ACCN1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:200 (Rat brain membranes)
• Immunogen: Synthetic peptide corresponding to aa2-18 (DLKES PSEGS LQPSS IQC) of human ASIC2 (Accession # Q16515). The epitope is not specific for ASIC2b (MDEG2) splice variant. Epitope Location: Intracellular, N-terminus.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot of rat brain membranes (25ug) Lane 1: using MBS610771 (1:200). Lane 2: Preincubated with MBS610771A.)

Product Categories/Family for anti-ACCN1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 9998944
• NCBI GeneID: 40
• NCBI Accession #: NP_001085.2
• NCBI GenBank Nucleotide #: NM_001094.4
• UniProt Accession #: Q16515; Q13553; Q6DJU1; Q8N3E2
• Molecular Weight: 57,709 Da
• NCBI Official Full Name: amiloride-sensitive cation channel 1, neuronal isoform 2
• NCBI Official Synonym Full Names: amiloride-sensitive cation channel 1, neuronal
• NCBI Official Symbol: ACCN1
• NCBI Official Synonym Symbols: ACCN; BNC1; MDEG; ASIC2; BNaC1; ASIC2a; hBNaC1
• NCBI Protein Information: amiloride-sensitive cation channel 1, neuronal; degenerin; OTTHUMP00000163794; brain sodium channel 1; acid-sensing ion channel 2; mammalian degenerin homolog; amiloride-sensitive brain sodium channel; amiloride-sensitive cation channel neuronal 1; neuronal amiloride-sensitive cation channel 1
• UniProt Protein Name: Amiloride-sensitive cation channel 1, neuronal
• UniProt Gene Name: ACCN1
• UniProt Synonym Gene Names: ACCN; BNAC1; MDEG
• UniProt Entry Name: ACCN1_HUMAN

NCBI Description

This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq]

Uniprot Description

ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Transporter; Transporter, ion channel; Channel, cation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cell soma; integral to plasma membrane; dendritic spine; plasma membrane; synapse

Molecular Function: amiloride-sensitive sodium channel activity; protein binding; ion gated channel activity; voltage-gated sodium channel activity

Biological Process: central nervous system development; regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; monovalent inorganic cation transport; sensory perception of sour taste; detection of mechanical stimulus involved in sensory perception; peripheral nervous system development; synaptic transmission; positive regulation of synaptogenesis; regulation of membrane potential; sensory perception of sound; regulation of gene expression; regulation of vasoconstriction; regulation of blood coagulation; phototransduction; transmembrane transport; negative regulation of apoptosis