Rabbit anti-Human, Mouse ASB6 Polyclonal Antibody | anti-ASB6 antibody

ASB6 Rabbit pAb

Cat. Num. AAA4760391

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: ASB6; Polyclonal Antibody; ASB6 Rabbit pAb; ankyrin repeat and SOCS box containing 6; anti-ASB6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.9mg/ml (varies by lot)

• Applicable Applications for anti-ASB6 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:250-1:1000; IHC-P: 1:40-1:200
• Immunogen: Fusion protein of human ASB6
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of ASB6 in LO2 cell lysate using ASB6 Rabbit pAb at dilution 1/250)

Immunohistochemistry (IHC)

(Immunohistochemistry of ASB6 in paraffin-embedded Human tonsil tissue using ASB6 Rabbit pAb at dilution 1/50. Predicted cell location: Cytoplasm)

Related Product Information for anti-ASB6 antibody

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 8923516
• NCBI GeneID: 140459
• NCBI Accession #: NP_060343.1
• NCBI GenBank Nucleotide #: NM_017873.3
• UniProt Accession #: Q9NWX5; Q5SZB7; Q9BV15
• Molecular Weight: 47,136 Da
• NCBI Official Full Name: ankyrin repeat and SOCS box protein 6 isoform 1
• NCBI Official Synonym Full Names: ankyrin repeat and SOCS box containing 6
• NCBI Official Symbol: ASB6
• NCBI Protein Information: ankyrin repeat and SOCS box protein 6; ankyrin repeat and SOCS box-containing 6
• UniProt Protein Name: Ankyrin repeat and SOCS box protein 6
• Protein Family: Ankyrin repeat and SOCS box protein
• UniProt Gene Name: ASB6
• UniProt Synonym Gene Names: ASB-6
• UniProt Entry Name: ASB6_HUMAN

NCBI Description

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.5

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Binds APS. Identified in a complex with TCEB1 and TCEB2

By similarity. Interacts with CUL5 and RNF7. Ref.5

Subcellular location: Cytoplasm

By similarity.

Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes

By similarity.

Sequence similarities: Contains 6 ANK repeats.Contains 1 SOCS box domain.