Western Blot (WB)
(WB Suggested Anti-ASB6 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysateASB6 is supported by BioGPS gene expression data to be expressed in 721_B)
Rabbit ASB6 Polyclonal Antibody | anti-ASB6 antibody
ASB6 antibody - middle region
Western Blot (WB)
(WB Suggested Anti-ASB6 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysateASB6 is supported by BioGPS gene expression data to be expressed in 721_B)
Western Blot (WB)
(WB Suggested Anti-ASB6 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysateASB6 is supported by BioGPS gene expression data to be expressed in 721_B)
Target Description: ASB6 belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]
Uniprot Description
Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.5
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Binds APS. Identified in a complex with TCEB1 and TCEB2
By similarity. Interacts with CUL5 and RNF7. Ref.5
Subcellular location: Cytoplasm
By similarity.
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes
By similarity.
Sequence similarities: Contains 6 ANK repeats.Contains 1 SOCS box domain.
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Product Notes
The ASB6 asb6 (Catalog #AAA3211268) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ASB6 antibody - middle region reacts with Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish and may cross-react with other species as described in the data sheet. AAA Biotech's ASB6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the ASB6 asb6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LKMAELGLTR AADVLLRHGA NLNFEDPVTY YTALHIAVLR NQPDMVELLV. It is sometimes possible for the material contained within the vial of "ASB6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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