Rabbit anti-Human, Mouse ASB6 Polyclonal Antibody | anti-ASB6 antibody

ASB6 Polyclonal Antibody

Cat. Num. AAA2560822

• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen affinity purification
• Synonyms: ASB6; Polyclonal Antibody; ASB6 Polyclonal Antibody; Ankyrin repeat and SOCS box containing 6; Ankyrin repeat and SOCS box protein 6; ASB 6; ASB-6; FLJ20548; MGC1024; anti-ASB6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

• Applicable Applications for anti-ASB6 antibody: Immunohistochemistry (IHC), ELISA
• Application Notes: IHC 1:50-1:300, ELISA 1:5000-1:10000
• Immunogen: Fusion protein of human ASB6
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human tonsil tissue using ASB6 Polyclonal Antibody at dilution of 1:50(×200))

Related Product Information for anti-ASB6 antibody

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene.

Product Categories/Family for anti-ASB6 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 8923516
• NCBI GeneID: 140459
• NCBI Accession #: NP_060343.1; BC001719
• NCBI GenBank Nucleotide #: NP_060343.1
• UniProt Accession #: Q9NWX5
• NCBI Official Full Name: ankyrin repeat and SOCS box protein 6 isoform 1
• NCBI Official Synonym Full Names: ankyrin repeat and SOCS box containing 6
• NCBI Official Symbol: ASB6
• NCBI Protein Information: ankyrin repeat and SOCS box protein 6
• UniProt Protein Name: Ankyrin repeat and SOCS box protein 6
• Protein Family: Ankyrin repeat and SOCS box protein
• UniProt Gene Name: ASB6
• UniProt Synonym Gene Names: ASB-6
• UniProt Entry Name: ASB6_HUMAN

NCBI Description

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

Function: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ref.5

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Binds APS. Identified in a complex with TCEB1 and TCEB2

By similarity. Interacts with CUL5 and RNF7. Ref.5

Subcellular location: Cytoplasm

By similarity.

Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes

By similarity.

Sequence similarities: Contains 6 ANK repeats.Contains 1 SOCS box domain.