Rabbit anti-Human ARMCX3 Polyclonal Antibody | anti-ARMCX3 antibody

ARMCX3, CT (ARMCX3, ALEX3, Armadillo repeat-containing X-linked protein 3, ARM protein lost in epithelial cancers on chromosome X 3) (FITC)

Cat. Num. AAA6275284

• Gene Names: ARMCX3; ALEX3; dJ545K15.2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: ARMCX3; Polyclonal Antibody; CT (ARMCX3; ALEX3; Armadillo repeat-containing X-linked protein 3; ARM protein lost in epithelial cancers on chromosome X 3) (FITC); ARM protein lost in epithelial cancers on chromosome X 3; anti-ARMCX3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-ARMCX3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: ARMCX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-325 amino acids from the C-terminal region of human ARMCX3.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ARMCX3 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ARMCX3 antibody detected the ARMCX3 protein (arrow).)

Related Product Information for anti-ARMCX3 antibody

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq].

Product Categories/Family for anti-ARMCX3 antibody

Antibodies; Cancer Markers

References

Mou, Z., et al. J. Biol. Chem. 284(20):13629-13640(2009). Olsen, J.V., et al. Cell 127(3):635-648(2006). Olsen, J.V., et al. Cell 127(3):635-648(2006). Ross, M.T., et al. Nature 434(7031):325-337(2005). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 7705274
• NCBI GeneID: 51566
• NCBI Accession #: NP_057691.1
• NCBI GenBank Nucleotide #: NM_016607.3
• UniProt Accession #: Q9UH62; Q53HC6; Q7LCF5; Q9NPE4
• Molecular Weight: 42,501 Da
• NCBI Official Full Name: armadillo repeat-containing X-linked protein 3
• NCBI Official Synonym Full Names: armadillo repeat containing, X-linked 3
• NCBI Official Symbol: ARMCX3
• NCBI Official Synonym Symbols: ALEX3; dJ545K15.2
• NCBI Protein Information: armadillo repeat-containing X-linked protein 3; 1200004E24Rik; arm protein lost in epithelial cancers, X chromosome, 3; ARM protein lost in epithelial cancers on chromosome X 3
• UniProt Protein Name: Armadillo repeat-containing X-linked protein 3
• Protein Family: Armadillo repeat-containing X-linked protein
• UniProt Gene Name: ARMCX3
• UniProt Synonym Gene Names: ALEX3; Protein ALEX3
• UniProt Entry Name: ARMX3_HUMAN

NCBI Description

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ARMCX3: an armadillo-repeat protein. Armadillo proteins function in multiple processes including intracellular signalling, cytoskeletal regulation, and transcriptional regulation. Armadillo proteins include beta-catenin, the junctional plaque protein plakoglobin, the adenomatous polyposis coli (APC) tumour suppressor protein, and the nuclear transport factor importin-alpha.

Protein type: Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: integral to mitochondrial outer membrane

Biological Process: positive regulation of transcription from RNA polymerase II promoter