Immunohistochemistry (IHC)
(Anti-ARFL3 / ARL3 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.)
Rabbit anti-Human ARFL3 / ARL3 Polyclonal Antibody | anti-ARFL3 antibody
Rabbit Polyclonal to Human ARFL3 / ARL3
Immunohistochemistry (IHC)
(Anti-ARFL3 / ARL3 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-ARFL3 / ARL3 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5-7.5 ug/ml.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma.)
Western Blot (WB)
(Western blot of anti-ARL3 in A2058 cell line lysate (35 ug/lane). ARL3 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot of anti-ARL3 in A2058 cell line lysate (35 ug/lane). ARL3 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot of ARL3 (arrow) using rabbit polyclonal ARL3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ARL3 gene (Lane 2).)
Western Blot (WB)
(Western blot of ARL3 (arrow) using rabbit polyclonal ARL3 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ARL3 gene (Lane 2).)
NCBI and Uniprot Product Information
NCBI Description
ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]
Uniprot Description
ARL3: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. Belongs to the small GTPase superfamily. Arf family.
Protein type: G protein, monomeric, ARF; Cell cycle regulation; Cytoskeletal; G protein, monomeric
Chromosomal Location of Human Ortholog: 10q23.3
Cellular Component: Golgi membrane; Golgi apparatus; centrosome; cytoplasmic microtubule; spindle microtubule; midbody; nucleus; photoreceptor connecting cilium
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; microtubule binding; metal ion binding
Biological Process: photoreceptor cell development; smoothened signaling pathway; protein transport; metabolic process; organelle organization and biogenesis; small GTPase mediated signal transduction; intraflagellar transport; cytokinesis; post-Golgi vesicle-mediated transport; kidney development
Research Articles on ARFL3
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Product Notes
The ARFL3 arl3 (Catalog #AAA243904) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human ARFL3 / ARL3 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ARFL3 / ARL3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB). IHC-P (5 - 7.5 ug/ml), WB (1:1000). Researchers should empirically determine the suitability of the ARFL3 arl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ARFL3 / ARL3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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