Rabbit anti-Human GNA14 Polyclonal Antibody | anti-GNA14 antibody

GNA14, NT (GNA14, Guanine nucleotide-binding protein subunit alpha-14)

Cat. Num. AAA644725

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: GNA14; Polyclonal Antibody; NT (GNA14; Guanine nucleotide-binding protein subunit alpha-14); Anti -GNA14; anti-GNA14 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-GNA14 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunohistochemistry, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500; Immunohistochemistry: 1:10-50
• Immunogen: GNA14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human GNA14.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GNA14 Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the GNA14 antibody detected the GNA14 protein (arrow).)

Immunohistochemistry (IHC)

(GNA14 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GNA14 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-GNA14 antibody

This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.

Product Categories/Family for anti-GNA14 antibody

Antibodies; Abs to Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4758444
• NCBI GeneID: 9630
• NCBI Accession #: NP_004288.1
• NCBI GenBank Nucleotide #: NM_004297.3
• UniProt Accession #: O95837
• Molecular Weight: 41,571 Da
• NCBI Official Full Name: guanine nucleotide-binding protein subunit alpha-14
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), alpha 14
• NCBI Official Symbol: GNA14
• NCBI Protein Information: guanine nucleotide-binding protein subunit alpha-14; g alpha-14; G-protein subunit alpha-14; guanine nucleotide-binding protein 14
• UniProt Protein Name: Guanine nucleotide-binding protein subunit alpha-14
• Protein Family: Guanine nucleotide-binding protein
• UniProt Gene Name: GNA14
• UniProt Synonym Gene Names: G alpha-14
• UniProt Entry Name: GNA14_HUMAN

NCBI Description

This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.[provided by RefSeq, Feb 2009]

Uniprot Description

G-alpha 14: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(q) subfamily.

Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 9q21

Cellular Component: plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; platelet activation; metabolic process; dopamine receptor, phospholipase C activating pathway; blood coagulation; signal transduction