Testing Data
Rabbit anti-Human ApoA4 Polyclonal Antibody | anti-ApoA4 antibody
ApoA4 Antibody (NT)
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
Background: Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Chylomicrons are a fundamental class of apolipoproteins containing very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). Apolipoprotein A-IV (ApoA4) is a glycoprotein that exists as a free apolipoprotein in human plasma. ApoA4 activates the lecithin cholesterol acyl transferase to modulate the rate of lipid transfer protein (LTP) activity. Additional evidence suggests that ApoA4 may also act as an antioxidant to inhibit LDL oxidation in the atherosclerosis model.
NCBI and Uniprot Product Information
NCBI Description
Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Uniprot Description
APOA4: May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family.
Protein type: Lipid-binding; Endoplasmic reticulum; Cell adhesion; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol
Molecular Function: antioxidant activity; lipid transporter activity; protein binding; protein homodimerization activity; copper ion binding; cholesterol transporter activity; cholesterol binding; phosphatidylcholine binding; lipid binding
Biological Process: cholesterol metabolic process; phototransduction, visible light; positive regulation of fatty acid biosynthetic process; multicellular organismal lipid catabolic process; removal of superoxide radicals; lipid homeostasis; neurite regeneration; protein-lipid complex assembly; cholesterol efflux; lipoprotein metabolic process; lipid transport; cholesterol biosynthetic process; phosphatidylcholine metabolic process; cholesterol homeostasis; leukocyte adhesion; reverse cholesterol transport; phospholipid efflux; regulation of cholesterol absorption; innate immune response in mucosa; hydrogen peroxide catabolic process; response to lipid hydroperoxide; positive regulation of lipoprotein lipase activity; retinoid metabolic process; regulation of cholesterol transport
Research Articles on ApoA4
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Product Notes
The ApoA4 apoa4 (Catalog #AAA841029) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ApoA4 Antibody (NT) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ApoA4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blot: ~1:1000, IHC: ~1:10-1:50. Researchers should empirically determine the suitability of the ApoA4 apoa4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ApoA4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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