Apolipoprotein A-IV Recombinant Protein | APOA4 recombinant protein

Recombinant Human Apolipoprotein A-IV Protein

Cat. Num. AAA2556593

• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Apolipoprotein A-IV; Recombinant Human Apolipoprotein A-IV Protein; Apo-AIV; ApoA-IV; Apolipoprotein A4; APOA4; APOA4 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
• Sequence Length: 396

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Glu21-Ser396
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for APOA4 recombinant protein

Protein Construction: Recombinant Human Apolipoprotein A-IV is produced by our Mammalian expression system and the target gene encoding Glu21-Ser396 is expressed with a 6His tag at the C-terminus.

Background: Apolipoprotein A4 (APOA4) is a secreted protein that belongs to the apolipoprotein A1/A4/E family. Apoa-IV is a major component of HDL and chylomicrons. APOA4 is secreted into circulation on the surface of newly synthesized chylomicron particles. APOA4 play a role in the regulation of appetite and satiety in rodent models. APOA4 involved in chylomicrons and VLDL secretion and catabolism and required for efficient activation of lipoprotein lipase by ApoC-II. In addition, APOA4 is a potent activator of lecithin-cholesterol acyltransferase in vitro.

NCBI and Uniprot Product Information

• NCBI GI #: 93163358
• NCBI GeneID: 337
• UniProt Accession #: P06727; Q14CW8; Q6Q787; A8MSL6
• Molecular Weight: Molecular Mass: 44.4kDa; Actual Protein Molecular Mass: 44.4kDa
• NCBI Official Full Name: Apolipoprotein A-IV
• NCBI Official Synonym Full Names: apolipoprotein A4
• NCBI Official Symbol: APOA4
• NCBI Protein Information: apolipoprotein A-IV
• UniProt Protein Name: Apolipoprotein A-IV
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOA4
• UniProt Synonym Gene Names: Apo-AIV; ApoA-IV

NCBI Description

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]

Uniprot Description

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.