Rabbit anti-Human APC2 Polyclonal Antibody | anti-APC2 antibody

APC2, ID (Adenomatous Polyposis Coli Protein 2, Adenomatous Polyposis Coli Protein-like, APC-like, APCL)

Cat. Num. AAA6012284

• Gene Names: APC2; APCL
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunocytochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: APC2; Polyclonal Antibody; ID (Adenomatous Polyposis Coli Protein 2; Adenomatous Polyposis Coli Protein-like; APC-like; APCL); Anti -APC2; anti-APC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human APC2. Species sequence homology: mouse.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-APC2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: Suitable for use in ELISA, Immunocytochemistry, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 18aa from near the center of human APC2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2ug/ml.)

Related Product Information for anti-APC2 antibody

APOC2 is secreted in plasma where it is a component of very low density lipoprotein. The protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in the gene encoding this protein cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.

Product Categories/Family for anti-APC2 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 4704623
• NCBI GeneID: 10297
• UniProt Accession #: O95996; Q05BW4; Q9UBZ1; Q9UEM8; Q9UQJ8; Q9UQJ9; Q9Y632
• Molecular Weight: 243,949 Da
• NCBI Official Full Name: APC2 protein
• NCBI Official Synonym Full Names: adenomatosis polyposis coli 2
• NCBI Official Symbol: APC2
• NCBI Official Synonym Symbols: APCL
• NCBI Protein Information: adenomatous polyposis coli protein 2; adenomatous polyposis coli like
• UniProt Protein Name: Adenomatous polyposis coli protein 2
• Protein Family: Acetophenone carboxylase
• UniProt Gene Name: APC2
• UniProt Synonym Gene Names: APCL; APC-like
• UniProt Entry Name: APC2_HUMAN

Uniprot Description

APCL: Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. Belongs to the adenomatous polyposis coli (APC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: microtubule cytoskeleton; Golgi membrane; Golgi apparatus; perinuclear region of cytoplasm; cytoplasmic microtubule; cytoplasm; actin filament; catenin complex

Molecular Function: protein binding; microtubule binding; beta-catenin binding

Biological Process: Wnt receptor signaling pathway