Western Blot (WB)
(AP4M1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the AP4M1 antibody detected the AP4M1 protein (arrow).)
Rabbit AP4M1 Polyclonal Antibody | anti-AP4M1 antibody
AP4M1 Antibody (Center)
Western Blot (WB)
(AP4M1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the AP4M1 antibody detected the AP4M1 protein (arrow).)
Western Blot (WB)
(AP4M1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the AP4M1 antibody detected the AP4M1 protein (arrow).)
complex. The encoded protein belongs to the adaptor complexes
medium subunits family. This AP-4 complex is involved in the
recognition and sorting of cargo proteins with tyrosine-based
motifs from the trans-golgi network to the endosomal-lysosomal
system.
Matsuda, S., et al. Neuron 57(5):730-745(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Simmen, T., et al. Nat. Cell Biol. 4(2):154-159(2002)
Boehm, M., et al. EMBO J. 20(22):6265-6276(2001)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]
Uniprot Description
AP4M1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. Belongs to the adaptor complexes medium subunit family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: clathrin adaptor complex; Golgi trans cisterna; AP-type membrane coat adaptor complex; coated pit; trans-Golgi network
Molecular Function: transporter activity
Biological Process: vesicle-mediated transport; intracellular protein transport; Golgi to endosome transport
Disease: Spastic Paraplegia 50, Autosomal Recessive
Research Articles on AP4M1
Similar Products
Product Notes
The AP4M1 ap4m1 (Catalog #AAA9207056) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 223-251. The AP4M1 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's AP4M1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AP4M1 ap4m1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AP4M1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
