Rabbit AP4M1 Polyclonal Antibody | anti-AP4M1 antibody

Anti-AP4M1 Antibody

Cat. Num. AAA417535

• Gene Names: AP4M1; MU-4; CPSQ3; SPG50; MU-ARP2
• Reactivity: Human. Predicted: Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: AP4M1; Polyclonal Antibody; Anti-AP4M1 Antibody; anti-AP4M1 antibody

• Host: Rabbit
• Reactivity: Human. Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 1598

• Applicable Applications for anti-AP4M1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA titer: 1:20,000-1:80,000; Western blot analysis: 1:500-1:1,000; Optimal dilutions/concentrations should be determined by the end user
• Storage Buffer: PBS, pH 7.4 with 0.02% sodium azide.
• Immunogen: Rabbit polyclonal AP4M1(1) antibody was raised against a recombinate human AP4M1 protein 285-453aa (BC018705).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-AP4M1 antibody

This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]

References

(1) Abou Jamra,R., Philippe,O., et al.Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature. Am. J. Hum. Genet. 88 (6), 788-795 (2011)

NCBI and Uniprot Product Information

• NCBI GI #: 17511693
• NCBI GeneID: 9179
• Molecular Weight: 49,977 Da
• NCBI Official Full Name: Homo sapiens adaptor-related protein complex 4, mu 1 subunit, mRNA
• NCBI Official Synonym Full Names: adaptor-related protein complex 4, mu 1 subunit
• NCBI Official Symbol: AP4M1
• NCBI Official Synonym Symbols: MU-4; CPSQ3; SPG50; MU-ARP2
• NCBI Protein Information: AP-4 complex subunit mu-1; AP-4 adaptor complex mu subunit; adapter-related protein complex 4 mu-1 subunit; adapter-related protein complex 4 subunit mu-1; adaptor-related protein complex 4 subunit mu-1; adaptor-related protein complex AP-4 mu4 subunit; mu subunit of AP-4; mu-adaptin-related protein 2; mu-adaptin-related protein-2; mu4-adaptin
• UniProt Protein Name: AP-4 complex subunit mu-1
• Protein Family: AP-4 complex
• UniProt Gene Name: AP4M1
• UniProt Entry Name: AP4M1_HUMAN

NCBI Description

This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. [provided by RefSeq, Jul 2008]

Uniprot Description

AP4M1: Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. Belongs to the adaptor complexes medium subunit family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: clathrin adaptor complex; Golgi trans cisterna; AP-type membrane coat adaptor complex; coated pit; trans-Golgi network

Molecular Function: transporter activity

Biological Process: vesicle-mediated transport; intracellular protein transport; Golgi to endosome transport

Disease: Spastic Paraplegia 50, Autosomal Recessive