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Testing Data

Rabbit AP3B1 Polyclonal Antibody | anti-AP3B1 antibody

AP3B1 Antibody

Gene Names
AP3B1; PE; HPS; HPS2; ADTB3; ADTB3A
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunoprecipitation
Purity
Antigen affinity purification
Synonyms
AP3B1; Polyclonal Antibody; AP3B1 Antibody; ADTB3; ADTB3A; HPS; HPS2; PE; anti-AP3B1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Sequence Length
1045
Applicable Applications for anti-AP3B1 antibody
ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP)
Application Notes
WB: 1:500-1:5000
Immunogen
Fusion protein of AP3B1
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-13384 / sc-69447
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles

Testing Data

Testing Data

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
116,195 Da
NCBI Official Full Name
AP-3 complex subunit beta-1 isoform 2
NCBI Official Synonym Full Names
adaptor-related protein complex 3, beta 1 subunit
NCBI Official Symbol
AP3B1
NCBI Official Synonym Symbols
PE; HPS; HPS2; ADTB3; ADTB3A
NCBI Protein Information
AP-3 complex subunit beta-1; AP-3 complex beta-3A subunit; adaptor protein complex AP-3 subunit beta-1; adaptor-related protein complex 3 subunit beta-1; beta-3A-adaptin; clathrin assembly protein complex 3 beta-1 large chain
UniProt Protein Name
AP-3 complex subunit beta-1
Protein Family
UniProt Gene Name
AP3B1
UniProt Synonym Gene Names
ADTB3A
UniProt Entry Name
AP3B1_HUMAN

NCBI Description

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

Uniprot Description

AP3B1: a subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. Mutations in AP3B1 cause defects of various cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes, and are the cause of Hermansky-Pudlak syndrome 2. Two alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 5q14.1

Cellular Component: Golgi apparatus; membrane; lysosomal membrane; clathrin coated vesicle membrane

Molecular Function: GTP-dependent protein binding; protein phosphatase binding

Biological Process: intracellular protein transport; protein targeting to lysosome; melanosome organization and biogenesis; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of NK T cell differentiation; blood coagulation; anterograde axon cargo transport

Disease: Hermansky-pudlak Syndrome 2

Research Articles on AP3B1

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Product Notes

The AP3B1 ap3b1 (Catalog #AAA2530246) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AP3B1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's AP3B1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP). WB: 1:500-1:5000. Researchers should empirically determine the suitability of the AP3B1 ap3b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AP3B1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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