Western Blot (WB)
(Anti-Annexin A2 antibody, MBS175289, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: Rat Ovary Tissue LysateLane 4: MCF-7 Cell LysateLane 5: SMMC Cell LysateLane 6: A549 Cell LysateLane 7: JURKAT Cell Lysate )
Rabbit Annexin A2 Polyclonal Antibody | anti-ANXA2 antibody
Anti-Annexin A2 antibody
Concentration: 1ug/ml
Tested Species: Hu, Rat, Ms
Concluded Species: -
Antigen Retrieval: -
IHC-P
Concentration: 1ug/ml
Tested Species: Hu, Rat, Ms
Concluded Species: -
Antigen Retrieval: By Heat
IHC-F:
Concentration: 1ug/ml
Tested Species: Hu, Rat, Ms
Concluded Species: -
Antigen Retrieval: -
ICC: -
Tested Species: -
Concluded Species: -
Antigen Retrieval: -
Other applications have not been tested.
Optimal dilutions should be determined by end user.
Western Blot (WB)
(Anti-Annexin A2 antibody, MBS175289, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: Rat Ovary Tissue LysateLane 4: MCF-7 Cell LysateLane 5: SMMC Cell LysateLane 6: A549 Cell LysateLane 7: JURKAT Cell Lysate )
Western Blot (WB)
(Anti-Annexin A2 antibody, MBS175289, Western blottingLane 1: Rat Testis Tissue LysateLane 2: Rat Lung Tissue LysateLane 3: Rat Ovary Tissue LysateLane 4: MCF-7 Cell LysateLane 5: SMMC Cell LysateLane 6: A549 Cell LysateLane 7: JURKAT Cell Lysate )
Immunohistochemistry (IHC)
(Anti-Annexin A2 antibody, MBS175289, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Annexin A2 antibody, MBS175289, IHC(P)IHC(P): Human Intestinal Cancer Tissue )
Background: Annexin A2 also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. The ANXA2 gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein is a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. Richard et al.(1994) presented an integration of the physical, expression, and genetic maps of human chromosome 15. They placed the ANXA2 gene in their region IV, i.e., 15q21-q22, thus confirming the previous localization.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: extrinsic to plasma membrane; extracellular space; cell surface; protein complex; lysosomal membrane; late endosome membrane; early endosome; lipid particle; cell cortex; lipid raft; ruffle; extracellular matrix; membrane; perinuclear region of cytoplasm; plasma membrane; melanosome; basement membrane; midbody; nucleus; sarcolemma; vesicle; endosome
Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; calcium-dependent protein binding; Rab GTPase binding
Biological Process: fibrinolysis; positive regulation of fibroblast proliferation; collagen fibril organization; negative regulation of catalytic activity; positive regulation of vesicle fusion; protein heterotetramerization; positive regulation of binding; positive regulation of protein amino acid phosphorylation; angiogenesis; lipid raft formation; body fluid secretion; membrane budding
Research Articles on ANXA2
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Product Notes
The ANXA2 anxa2 (Catalog #AAA175289) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Annexin A2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Annexin A2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin. WB: Concentration: 1ug/ml Tested Species: Hu, Rat, Ms Concluded Species: - Antigen Retrieval: - IHC-P Concentration: 1ug/ml Tested Species: Hu, Rat, Ms Concluded Species: - Antigen Retrieval: By Heat IHC-F: Concentration: 1ug/ml Tested Species: Hu, Rat, Ms Concluded Species: - Antigen Retrieval: - ICC: - Tested Species: - Concluded Species: - Antigen Retrieval: - Other applications have not been tested. Optimal dilutions should be determined by end user. Researchers should empirically determine the suitability of the ANXA2 anxa2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Annexin A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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