Sheep Ancient Ubiquitous Protein 1, aa8-60 Polyclonal Antibody | anti-AUP1 antibody

Ancient Ubiquitous Protein 1, aa8-60 (AUP1)

Cat. Num. AAA621618

• Reactivity: Bovine, Human, Rat, Sheep
• Applications: Western Blot, Immunohistochemistry
• Purity: Serum; Serum
• Synonyms: Ancient Ubiquitous Protein 1; aa8-60; Polyclonal Antibody; aa8-60 (AUP1); Anti -Ancient Ubiquitous Protein 1; anti-AUP1 antibody

• Host: Sheep
• Reactivity: Bovine, Human, Rat, Sheep
• Clonality: Polyclonal
• Specificity: Recognizes ancient ubiquitous protein 1. Species crossreactivity: bovine, sheep, human and rat.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a lyophilized powder. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-AUP1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry and Western Blot.; Dilution: Immunohistochemistry (paraffin embedded and frozen tissues):1:500 -1:6000.; Western Blot: 1:500 -1:6000.
• Immunogen: A synthetic peptide (HVFLVSCALPDSV) corresponding to the aa48-60 of human ancient ubiquitous protein 1 conjugated to blue carrier protein.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-AUP1 antibody

AUP1 contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain thay may be involved in binding ubiquitin-conjugating enzymes. The unprocessed precusor is of 476 amino acids in length and has an estimated molecular weight of 53kD.

Product Categories/Family for anti-AUP1 antibody

Antibodies; Abs to Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 31712030
• NCBI GeneID: 550
• NCBI Accession #: NP_853553.1
• NCBI GenBank Nucleotide #: NM_181575.3
• UniProt Accession #: Q68CX8; Q9Y679
• Molecular Weight: 41,587 Da
• NCBI Official Full Name: ancient ubiquitous protein 1
• NCBI Official Synonym Full Names: ancient ubiquitous protein 1
• NCBI Official Symbol: AUP1
• NCBI Protein Information: ancient ubiquitous protein 1; OTTHUMP00000160424; OTTHUMP00000202724
• UniProt Protein Name: Putative uncharacterized protein DKFZp686P12272
• Protein Family: Ancient ubiquitous protein
• UniProt Gene Name: DKFZp686P12272
• UniProt Entry Name: Q68CX8_HUMAN

NCBI Description

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. [provided by RefSeq]

Uniprot Description

AUP1: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Endoplasmic reticulum; Transferase

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane

Molecular Function: protein binding