Western Blot (WB)
(MMP11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MMP11 antibody detected the MMP11 protein (arrow).)
Rabbit anti-Human MMP11 Polyclonal Antibody | anti-MMP11 antibody
MMP11 Antibody (C-term)
Western Blot (WB)
(MMP11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MMP11 antibody detected the MMP11 protein (arrow).)
Western Blot (WB)
(MMP11 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MMP11 antibody detected the MMP11 protein (arrow).)
Immunohistochemistry (IHC)
(MMP11 Antibody (C-term) (MBS9207091)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(MMP11 Antibody (C-term) (MBS9207091)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MMP11 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. However, the enzyme encoded by this
gene is activated intracellularly by furin within the constitutive
secretory pathway. Also in contrast to other MMP's, this enzyme
cleaves alpha 1-proteinase inhibitor but weakly degrades structural
proteins of the extracellular matrix.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Ban, J.Y., et al. Life Sci. 86 (19-20), 756-759 (2010) :
Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :
NCBI and Uniprot Product Information
NCBI Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Uniprot Description
MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.
Protein type: Protease; Secreted, signal peptide; EC 3.4.24.-; Secreted; Extracellular matrix
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: proteinaceous extracellular matrix; Golgi lumen; extracellular region
Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; negative regulation of fat cell differentiation; proteolysis
Research Articles on MMP11
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Product Notes
The MMP11 mmp11 (Catalog #AAA9207091) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 399-428. The MMP11 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MMP11 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the MMP11 mmp11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMP11, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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