Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using AMOTL1 antibody.)
Rabbit anti-Human, Mouse AMOTL1 Polyclonal Antibody | anti-AMOTL1 antibody
AMOTL1 Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using AMOTL1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using AMOTL1 antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Description
AMOTL1: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Belongs to the angiomotin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 11q14.3
Cellular Component: signalosome; tight junction; lamellipodium; apical plasma membrane; cytoplasm; cytoplasmic vesicle; cytosol; cell junction
Molecular Function: identical protein binding; protein binding
Biological Process: Wnt receptor signaling pathway; positive regulation of blood vessel endothelial cell migration
Research Articles on AMOTL1
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Product Notes
The AMOTL1 amotl1 (Catalog #AAA9407080) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AMOTL1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's AMOTL1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the AMOTL1 amotl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AMOTL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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