Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using XRCC1 antibody.)
Rabbit XRCC1 Polyclonal Antibody | anti-XRCC1 antibody
XRCC1 Antibody
Immunohistochemistry: 1:50~1:100
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using XRCC1 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using XRCC1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using XRCC1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using XRCC1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from JK cells (Lane 2), HuvEc cells (Lane 3) and COS7 cells (Lane 4), using XRCC1 antiobdy. The lane on the left is treated with systhesized peptide.)
Western Blot (WB)
(Western blot analysis of extracts from JK cells (Lane 2), HuvEc cells (Lane 3) and COS7 cells (Lane 4), using XRCC1 antiobdy. The lane on the left is treated with systhesized peptide.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Uniprot Description
XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; enzyme binding; damaged DNA binding
Biological Process: single strand break repair; base-excision repair; DNA repair
Research Articles on XRCC1
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Product Notes
The XRCC1 xrcc1 (Catalog #AAA9413535) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The XRCC1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's XRCC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the XRCC1 xrcc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "XRCC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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