Rabbit alpha Internexin Polyclonal Antibody | anti-INA antibody

alpha Internexin antibody

Cat. Num. AAA835849

• Gene Names: INA; NEF5; NF-66; TXBP-1
• Applications: Western Blot
• Purity: alpha Internexin antibody was purified by immunoaffinity chromatography.
• Synonyms: alpha Internexin; Polyclonal Antibody; alpha Internexin antibody; Polyclonal alpha Internexin; Anti-alpha Internexin; Internexin-alpha; Internexin alpha; Internexin; anti-INA antibody

• Host: Rabbit
• Clonality: Polyclonal
• Purity/Purification: alpha Internexin antibody was purified by immunoaffinity chromatography.
• Form/Format: Supplied in liquid form in PBS buffer (no MG2+ or Ca2+), pH 7.4, 150 mm NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 499

• Applicable Applications for anti-INA antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Biological Significance: alpha-Internexin, is a Class IV intermediate filament approximately 66 KDa. The protein was originally purified from rat optic nerve and spinal cord. The protein copurifies with other neurofilament subunits, as it was originally discovered, however in some mature neurons it can be the only neurofilament expressed. The protein is present in developing neuroblasts and in the Central Nervous System of adults. The protein is a major component of the intermediate filament network in small interneurons and cerebellar granule cells, where it is present in the parallel fibers.
• Cross-Reactivity: Human
• Immunogen: alpha Internexin antibody was raised in Rabbit using the peptide sequence around aa 491~495(E-T-T-I-S)derived from Human A-Internexin as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of extract from Rat brain and Rat hippocampus Tissue using a-lnternexin antibody)

Related Product Information for anti-INA antibody

Rabbit polyclonal alpha Internexin antibody

Product Categories/Family for anti-INA antibody

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 14249342
• NCBI GeneID: 9118
• NCBI Accession #: NP_116116.1
• NCBI GenBank Nucleotide #: NM_032727.3
• UniProt Accession #: Q16352; Q9BRC5; B1AQK0
• Molecular Weight: 55,391 Da
• NCBI Official Full Name: alpha-internexin
• NCBI Official Synonym Full Names: internexin neuronal intermediate filament protein, alpha
• NCBI Official Symbol: INA
• NCBI Official Synonym Symbols: NEF5; NF-66; TXBP-1
• NCBI Protein Information: alpha-internexin
• UniProt Protein Name: Alpha-internexin
• Protein Family: Alpha-internexin
• UniProt Gene Name: INA
• UniProt Synonym Gene Names: NEF5; Alpha-Inx; NF-66; Neurofilament-66
• UniProt Entry Name: AINX_HUMAN

NCBI Description

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons. [provided by RefSeq, Jun 2009]

Uniprot Description

INA: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Belongs to the intermediate filament family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: nucleoplasm; extracellular space; intermediate filament cytoskeleton; nuclear membrane; neurofilament

Molecular Function: structural constituent of cytoskeleton

Biological Process: substantia nigra development; neurofilament cytoskeleton organization and biogenesis; cell differentiation