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Chemical Structure

Y-27632 2HCl, Inhibitor

Y-27632 2HCl

Purity
>98%
Synonyms
Y-27632 2HCl; inhibitor
Ordering
For Research Use Only!
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 31.22 mL (1 mg); 156.1 mL (5 mg); 312.21mL (10 mg)
0.5 mM: 6.24 mL (1 mg); 31.22 mL (5 mg); 62.44 mL (10 mg)
1 mM: 3.12 mL (1 mg); 15.61 mL (5 mg); 31.22 mL (10 mg)
5 mM: 0.62 mL (1 mg); 3.12 mL (5 mg); 6.24 mL (10 mg) (varies by lot)
CAS Number
146986-50-7, 129830-38-2
Formula
C14H21N3O.2HCl
SMILES
C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl
Actions
Inhibitor
In Vivo Solvent
Saline
Solubility (DMSO)
64 mg/mL warmed (199.83 mM)
Solubility (Ethanol)
<1 mg/mL (<1 mM)
Solubility (in vivo)
30 mg/mL
Solubility (Water)
14 mg/mL (43.71 mM)
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder

Chemical Structure

Chemical Structure
Related Product Information for Y-27632 2HCl, inhibitor
Y-27632 is a Rho-Associated Coil Kinase (ROCK) inhibitor that increases the cloning efficiency of human embryonic stem cells (hESCs).
References
XinYan, .et al. Establishment of CSUASOi001-A, a non-integrated induced pluripotent stem cell line from urine-derived cells of a Chinese patient carrying RS1 gene mutation, Stem Cell Res, 2019, May 17
Daniela F. Duarte Campos, .et al. Corneal bioprinting utilizing collagen-based bioinks and primary human keratocytes, J Biomed Mater Res A, 2019, April 22
Scott Bell, .et al. Mutations in ACTL6B Cause Neurodevelopmental Deficits and Epilepsy and Lead to Loss of Dendrites in Human Neurons, Am J Hum Genet, 2019, May 2;104(5):815-834 PMID: 31031012
Ooi J, .et al. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects, Cell Rep, 2019, Feb 26;26(9):2494-2508 PMID: 30811996
Scott Bell, .et al. Disruption of GRIN2B Impairs Differentiation in Human Neurons, Stem Cell Reports, 2018, Jul 10; 11(1):183-196 PMID: 29937144
Christina Zarouchlioti, .et al. Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity, Am J Hum Genet, 2018, Apr 5; 102(4): 528-539 PMID: 29526280
Ai Takemoto, .et al. A critical role of platelet TGF-?? release in podoplanin-mediated tumour invasion and metastasis, Sci Rep, 2017, 7: 42186 PMID: 28176852
Scott Bell, .et al. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing, Stem Cells Transl Med, 2017, Mar; 6(3): 886-896 PMID: 28170165

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Product Notes

The Y-27632 2HCl (Catalog #AAA385766) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Y-27632 2HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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