Rabbit AGXT2 Polyclonal Antibody | anti-AGXT2 antibody

Anti-AGXT2 Antibody

Cat. Num. AAA415809

• Gene Names: AGXT2; AGT2; DAIBAT
• Reactivity: Human. Not yet tested in other species
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: AGXT2; Polyclonal Antibody; Anti-AGXT2 Antibody; anti-AGXT2 antibody

• Host: Rabbit
• Reactivity: Human. Not yet tested in other species
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 514

• Applicable Applications for anti-AGXT2 antibody: Peptide ELISA (EIA), Western Blot, Immunohistochemistry (IHC)
• Application Notes: Peptide ELISA titer: 1:10,000-1:40,000; Western blot analysis: 1:500-1:1,000; Immunohistochemistry: 1:100-1:500; Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Immunohistochemistry (IHC)

Related Product Information for anti-AGXT2 antibody

This gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

References

(1) Rodionov,R.N., Murry,D.J., Vaulman,S.F., et al. Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production. J. Biol. Chem. 285 (8), 5385-5391 (2010)

NCBI and Uniprot Product Information

• NCBI GI #: 13994255
• NCBI GeneID: 64902
• NCBI Accession #: NP_114106.1
• NCBI GenBank Nucleotide #: NM_031900.3
• Molecular Weight: 49,297 Da
• NCBI Official Full Name: alanine--glyoxylate aminotransferase 2, mitochondrial
• NCBI Official Synonym Full Names: alanine--glyoxylate aminotransferase 2
• NCBI Official Symbol: AGXT2
• NCBI Official Synonym Symbols: AGT2; DAIBAT
• NCBI Protein Information: alanine--glyoxylate aminotransferase 2, mitochondrial; (R)-3-amino-2-methylpropionate--pyruvate transaminase; beta-ALAAT II; beta-alanine-pyruvate aminotransferase
• UniProt Protein Name: Alanine--glyoxylate aminotransferase 2, mitochondrial
• Protein Family: Alanine--glyoxylate aminotransferase
• UniProt Gene Name: AGXT2
• UniProt Entry Name: AGT2_HUMAN

NCBI Description

The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

Uniprot Description

AGXT2: is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]

Protein type: Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; EC 2.6.1.40; EC 2.6.1.44

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: beta-alanine-pyruvate transaminase activity; alanine-glyoxylate transaminase activity; (R)-3-amino-2-methylpropionate-pyruvate transaminase activity; pyridoxal phosphate binding

Biological Process: pyrimidine nucleoside catabolic process; positive regulation of nitric oxide biosynthetic process; glyoxylate catabolic process; pyrimidine base metabolic process; glyoxylate metabolic process; nucleobase, nucleoside and nucleotide metabolic process; glycine biosynthetic process, by transamination of glyoxylate; L-alanine catabolic process, by transamination