Rabbit anti-Human AGTRAP Polyclonal Antibody | anti-AGTRAP antibody

AGTRAP Antibody

Cat. Num. AAA9412854

• Gene Names: AGTRAP; ATRAP
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: AGTRAP; Polyclonal Antibody; AGTRAP Antibody; ATRAP; anti-AGTRAP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total AGTRAP protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.8 mg/ml (varies by lot)
• Sequence Length: 152

• Applicable Applications for anti-AGTRAP antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human angiotensin II receptor-associated protein
• Target Name: AGTRAP
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/40.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.)

Related Product Information for anti-AGTRAP antibody

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.

Product Categories/Family for anti-AGTRAP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 93588491
• NCBI GeneID: 57085
• NCBI Accession #: NP_001035284.1
• NCBI GenBank Nucleotide #: NM_001040194.1
• UniProt Accession #: Q6RW13; Q5SNV4; Q5SNV5; Q96AC0; Q96PL4; Q9NRW9; A8MVQ5
• Molecular Weight: 11,948 Da
• NCBI Official Full Name: type-1 angiotensin II receptor-associated protein isoform b
• NCBI Official Synonym Full Names: angiotensin II receptor-associated protein
• NCBI Official Symbol: AGTRAP
• NCBI Official Synonym Symbols: ATRAP
• NCBI Protein Information: type-1 angiotensin II receptor-associated protein
• UniProt Protein Name: Type-1 angiotensin II receptor-associated protein
• Protein Family: Type-1 angiotensin II receptor-associated protein
• UniProt Gene Name: AGTRAP
• UniProt Synonym Gene Names: ATRAP
• UniProt Entry Name: ATRAP_HUMAN

NCBI Description

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Description

AGTRAP: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; integral to membrane; plasma membrane; cell cortex

Molecular Function: protein binding; angiotensin type II receptor activity

Biological Process: regulation of blood pressure; response to hypoxia