Western Blot (WB)
(AGTRAP Antibody (C-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the AGTRAP Antibody detected the AGTRAP protein (arrow).)
Rabbit anti-Human AGTRAP Polyclonal Antibody | anti-AGTRAP antibody
AGTRAP Antibody (C-term)
Western Blot (WB)
(AGTRAP Antibody (C-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the AGTRAP Antibody detected the AGTRAP protein (arrow).)
Western Blot (WB)
(AGTRAP Antibody (C-term) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the AGTRAP Antibody detected the AGTRAP protein (arrow).)
plasma membrane and perinuclear vesicular structures. The gene
product interacts with the angiotensin II type I receptor and
negatively regulates angiotensin II signaling. Alternative splicing
of this gene generates multiple transcript variants encoding
different isoforms.
Godin, C.M., et al. Mol. Pharmacol. 77(3):388-395(2010)
Rabbitts, J.A., et al. J. Physiol. (Lond.) 587 (PT 22), 5441-5449 (2009) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
AGTRAP: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; integral to membrane; cell cortex
Molecular Function: protein binding; angiotensin type II receptor activity
Biological Process: regulation of blood pressure; response to hypoxia
Research Articles on AGTRAP
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Product Notes
The AGTRAP agtrap (Catalog #AAA9208207) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 133-159. The AGTRAP Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AGTRAP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the AGTRAP agtrap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AGTRAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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