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Immunohistochemistry (IHC) (Huma Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Rabbit anti-Mouse, Human ADCY1 / Adenylate Cyclase 1 Polyclonal Antibody | anti-ADCY1 antibody

Anti-ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) IHC-plus

Gene Names
ADCY1; AC1; DFNB44
Reactivity
Mouse, Human
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Immunoaffinity purified
Synonyms
ADCY1 / Adenylate Cyclase 1; Polyclonal Antibody; Anti-ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) IHC-plus; Rabbit Polyclonal (IgG) to Human ADCY1 / Adenylate Cyclase 1; Human ADCY1 / Adenylate Cyclase 1; 3; 5-cyclic AMP synthetase; Adenylate cyclase type I; AC1; Adenylate cyclase type 1; Adenylyl cyclase 1; ATP pyrophosphate-lyase 1; Adenyl cyclase; Adenylate cyclase 1 (brain); Adenylate cyclase; type i; ATP pyrophosphate-lyase; anti-ADCY1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse, Human
Clonality
Polyclonal
Isotype
IgG
Specificity
ADCY1 Antibody detects endogenous levels of total ADCY1 protein.
Purity/Purification
Immunoaffinity purified
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Concentration
1 mg/ml (varies by lot)
Sequence Length
1119
Applicable Applications for anti-ADCY1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA)
Application Notes
ELISA (1:40000)
IHC-P (10 ug/ml)
WB (1:500 - 1:1000)
Immunogen
ADCY1 / Adenylate Cyclase 1 antibody was raised against synthetic peptide from human ADCY1 (aa231-280).
Immunogen Description
Synthetic peptide from human ADCY1 (aa231-280).
Antigen Modification
aa231-280
Target Species
Human
Preparation and Storage
Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Huma Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC) (Huma Testis: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Anti-ADCY1 / Adenylate Cyclase 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunohistochemistry (IHC) (Anti-ADCY1 / Adenylate Cyclase 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Western blot of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide.)

Western Blot (WB) (Western blot of extracts from COLO205 cells, using ADCY1 Antibody. The lane on the right is treated with the synthesized peptide.)
Related Product Information for anti-ADCY1 antibody
ADCY1 Antibody, 3,5-cyclic AMP synthetase Antibody, Adenylate cyclase type I Antibody, AC1 Antibody, Adenylate cyclase type 1 Antibody, Adenylyl cyclase 1 Antibody, ATP pyrophosphate-lyase 1 Antibody, Adenyl cyclase Antibody, Adenylate cyclase 1 (brain) Antibody, Adenylate cyclase, type i Antibody, ATP pyrophosphate-lyase Antibody Description: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
107
UniProt Accession #
Molecular Weight
123,440 Da
NCBI Official Full Name
Adenylate cyclase type 1
NCBI Official Synonym Full Names
adenylate cyclase 1 (brain)
NCBI Official Symbol
ADCY1
NCBI Official Synonym Symbols
AC1; DFNB44
NCBI Protein Information
adenylate cyclase type 1
UniProt Protein Name
Adenylate cyclase type 1
Protein Family
UniProt Gene Name
ADCY1
UniProt Entry Name
ADCY1_HUMAN

NCBI Description

This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Description

ADCY1: a calmodulin-sensitive adenylyl cyclase expressed in brain. The mouse protein is involved in pattern formation of the brain. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.

Protein type: Transporter, aquaporin family; Lyase; Nucleotide Metabolism - purine; Transporter; Membrane protein, multi-pass; Adenylyl cyclase; Membrane protein, integral; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: cytoplasm; integral to plasma membrane; lipid raft; nucleus; plasma membrane

Molecular Function: adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding

Biological Process: activation of protein kinase A; axonogenesis; cAMP biosynthetic process; cAMP-mediated signaling; circadian rhythm; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; innate immune response; long-term memory; nerve growth factor receptor signaling pathway; phospholipase C activation; regulation of circadian rhythm; renal water homeostasis; response to drug; response to lithium ion; signal transduction; synaptic transmission; transmembrane transport; water transport

Disease: Deafness, Autosomal Recessive 44

Research Articles on ADCY1

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Product Notes

The ADCY1 adcy1 (Catalog #AAA249587) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) IHC-plus reacts with Mouse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's ADCY1 / Adenylate Cyclase 1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA). ELISA (1:40000) IHC-P (10 ug/ml) WB (1:500 - 1:1000). Researchers should empirically determine the suitability of the ADCY1 adcy1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ADCY1 / Adenylate Cyclase 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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