Western Blot (WB)
(ACSS2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ACSS2 antibody detected the ACSS2 protein (arrow).)
Rabbit anti-Human ACSS2 Polyclonal Antibody | anti-ACSS2 antibody
ACSS2 Antibody (Center)
Western Blot (WB)
(ACSS2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ACSS2 antibody detected the ACSS2 protein (arrow).)
Western Blot (WB)
(ACSS2 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the ACSS2 antibody detected the ACSS2 protein (arrow).)
Immunohistochemistry (IHC)
(ACSS2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ACSS2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(ACSS2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ACSS2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
activation of acetate for use in lipid synthesis and energy
generation. The protein acts as a monomer and produces acetyl-CoA
from acetate in a reaction that requires ATP. Expression of this
gene is regulated by sterol regulatory element-binding proteins,
transcription factors that activate genes required for the
synthesis of cholesterol and unsaturated fatty acids. Alternative
splicing results in multiple transcript variants. [provided by
RefSeq].
Yilmaz, S., et al. Genomics 96(1):57-65(2010)
Ban, H.J., et al. BMC Genet. 11, 26 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Yun, M., et al. J. Nucl. Med. 50(8):1222-1228(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Uniprot Description
ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 6.2.1.1; Ligase; Carbohydrate Metabolism - pyruvate
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; cytosol
Molecular Function: acetate-CoA ligase activity; ATP binding; AMP binding
Biological Process: acetyl-CoA biosynthetic process from acetate; xenobiotic metabolic process; lipid biosynthetic process; propionate biosynthetic process; ethanol oxidation; acetate biosynthetic process
Research Articles on ACSS2
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Product Notes
The ACSS2 acss2 (Catalog #AAA9213321) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 261-290. The ACSS2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ACSS2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the ACSS2 acss2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACSS2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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